Bone is a highly dynamic tissue which is constantly being remodelled throughout life – it has recognised mechanical functions such as: providing rigidity and shape, support and protection for body structures and aids locomotion. It is continuously characterised by resorption and adsorption as a part of bone formation. Osteoclasts and osteoblasts cells are responsible for bone metabolism. It is the osteoblast cells which are important for bone formation and osteoclast cells which are responsible for initiating normal bone remodelling by degrading bone and mediating bone loss in pathologic conditions. Bone metabolism includes the activity of several hormones for example: osteocalcin, parathormone (PTH) and vitamin D.
Measurement of vitamin D levels is also very important when assessing the health of bones. It is known to play a vital function in regulating calcium levels and bone remodelling. Deficiencies in vitamin D levels are known to lead to osteomalacia in adults and rachitis in children. Diseases that affect bone and mineral metabolism can encompass a wide range of soft tissue and skeletal disorders. Majority of these disorders can be classed as osteoporosis, hyperparathyroidism, developmental disorders of bone, osteomalacia and Paget disease of bone.
Most Popular Bone & Mineral Metabolism ELISA Kits
- 25-OH Vitamin D ELISA Kit
- Calcitonin ELISA Kit
- Osteocalcin ELISA Kit
- Human Osteopontin ELISA Kit
- Parathyroid Hormone (PTH) Intact ELISA Kit