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EBV EA (Early Antigen) IgM ELISA Kit

  • Created on the 18 July, 2017.

BACKGROUND

Epstein–Barr virus (EBV) can also be referred to as human herpesvirus 4 (HHV-4) and it belongs to the family of viruses known as herpes. EBV is responsible for causing infectious mononucleosis, an illness which is associated with sore throat, fever, swollen lymph nodes and sometimes enlarged spleen. This virus is able to spread through many commonly bodily fluids, especially saliva. It is also able to spread through blood and semen, organ transplantations and blood transfusions. A large number of these viral infections have been linked to autoimmune diseases for example Sjögren’s syndrome, multiple sclerosis, dermatomyositis, systemic lupus erythematosus and rheumatoid arthritis. EBV Early antigen (EBV EA) can be associated to a number of different acute phase illness, however, after 3-6 months the levels become undetectable.

INTENDED USE

Human EBV EA-IgM ELISA kit is a procedure for analysing in-vitro quantitative levels of human IgM antibodies to the Epstein–Barr virus early antigen (EBV EA) using samples of plasma or serum. This assay has a minimum analytical sensitivity limit of 1.1 U/ml.

SENSITIVITY

The minimum detection sensitivity level of human Epstein–Barr virus early antigen (EBV EA) IgM using this human EBV EA-IgM ELISA kit was 1.1 U/ml. The dynamic assay range for this kit is 1.0 – 200.0 U/ml.

REFERENCES

  1. IgM serum antibodies to Epstein-Barr virus are uniquely present in a subset of patients with the chronic fatigue syndrome. In Vivo. (2004) 18 (2): 101-6. Lerner A.M., et al.
  2. Antibodies to early EBV, CMV, and HHV6 antigens in systemic lupus erythematosus patients. Scand J Rheumatol. (2015) 44 (2): 143-9. Rasmussen N.S., et al.
  3. Epstein-Barr virus specific marker molecules for early diagnosis of infectious mononucleosis. J Virol Methods. (1988) 21 (1-4): 133-46. Middeldorp J.M., Herbrink P.
  4. EBV reactivation serological profile in primary Sjögren’s syndrome: an underlying trigger of active articular involvement? Rheumatol Int. (2013) 33 (5): 1149-57. Pasoto S.G., et al.
  5. Antibodies to Epstein-Barr virus-induced early antigens in blood donors. Acta Virol. (1989) 33 (4): 344-8. Wohlrabe P., et al.

ADDITIONAL INFORMATION

  • Full Name: EBV EA (Early Antigen) IgM ELISA Kit
  • Reactivity: Human
  • Sample Type: Plasma, Serum
  • Sensitivity: 1.1 U/ml

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