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Glutamate ELISA Kit

  • Created on the 3 March, 2017.

BACKGROUND

Glutamate, in neuroscience is used to describe the anion of glutaminc acid in its functions as neurotransmitter that has the ability to send signals in the brain and throughout the nerves in the body. It is synthesised from glutamine using glutaminase enzyme as part of the glutamate-glutamine cycle within the central nervous system. This process usually occurs in the presynaptic neuron or even in the neighboring glial cells.

It is a major constituent of a large number of proteins and can also serve as a metabolic precursor for the neurotransmitter GABA, through the action of glutamate decarboxylase enzyme. Glutamate is vital for many bodily functions which includes sending messages for body movement, creation and the management of memory and regulating the human thought process. It is also very important during the development of the brain. Excess levels of glutamate in the brain have been linked with a number of neurological diseases for example Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS) and stroke. Also, difficulty in making or even using glutamate have been associated to many mental health disorders such as obsessive-compulsive disorder (OCD), autism, depression and schizophrenia.

INTENDED USE

Human glutamate ELISA kit can be used for measuring in vitro quantitative amounts of glutamate in human serum, EDTA-plasma and urine. This assay has a minimum sensitivity detection limit of 0.3 µg/ml.

SENSITIVITY

The minimum sensitivity detection limit of glutamate using this human glutamate ELISA kit was approximately 0.3 µg/ml. The dynamic assay range for this kit is 0.6 – 60 µg/ml.

REFERENCES

  1. Maintaining the presynaptic glutamate supply for excitatory neurotransmission. J Neurosci Res. (2015) 93 (7): 1031-44. Review. Marx M.C., et al.
  2. Glutamate as a neurotransmitter in the healthy brain. J Neural Transm (Vienna). (2014) 121 (8): 799-817. Review. Zhou Y. and Danbolt N.C.
  3. The glutamate hypothesis in ALS: pathophysiology and drug development. Curr Med Chem. (2014) 21 (31): 3551-75. Review. Blasco H., et al.
  4. Glutamate: a truly functional amino acid. Amino Acids. (2013) 45 (3): 413-8. Review. Brosnan J.T. and Brosnan M.E.
  5. Multiple sclerosis and glutamate excitotoxicity. Rev Neurosci. (2013) 24 (1): 71-88. Review. Kostic M., et al.

ADDITIONAL INFORMATION

  • Full Name: Glutamate ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum, EDTA-Plasma, Urine
  • Sensitivity: 0.3 µg/ml

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