Investigating IGSF11: Insights into Its Role in Immune Regulation and Disease

Introduction: Structural and Functional Overview

IGSF11 is a protein that falls under the immunoglobulin superfamily (IgSF) which consists of a range of cell surface and soluble proteins featuring immunoglobulin domains in their structure. The protein is also referred to as PVRL3 (Poliovirus Receptor Like 3). It has attracted interest, for its functions in immune regulation and possible links, to different diseases.

The IGS protein 11 is made up of Ig sections outside the cell membrane and a brief cytoplasmic tail, inside the cell membrane layer to support its connections with other proteins for activities like cell bonding and immune system responses in tissues such as the brain and epithelial tissues as well as immune cells where it plays varying biological functions crucial, for understanding its roles in the immune system.

Immune Response: Mechanisms and Pathways

Its presence on antigen cells is crucial as it influences the activation and control of T cells by engaging with receptors essential, for signalling pathways.

IGSF11 plays a role, in impacting responses by boosting T cell activation when interacting with its ligands on T cells It helps increase cytokine production and support T cell growth to kickstart adaptive immune responses. Additionally, IGS11 is involved in controlling T cell development which influences the equilibrium between effector and regulatory T cells important, for sustaining immune balance.

The potential of IGS11, as a target is underscored by its interaction with immune receptors. Adjustments to IGS11 activity could potentially impact T-cell responses in scenarios, like infections and vaccinations.

Autoimmunity: Implications in Disease Pathogenesis

Recent research has been looking into the connection, between IGS11 and autoimmune disorders which occur when the immune system wrongly attacks its antigens causing tissue damage and lasting inflammation issues in the body due to immune checkpoint malfunctions common in such conditions where IGS11 seems to have a twofold impact, in this scenario.

In disorders, like systemic lupus erythematosus (SLE) and rheumatoid arthritis changes in the way IGS11 gene behaves have been noticed. Higher IGS11 levels might play a role in disrupting tolerance levels boosting the activity of self-targeted T-cells. On the hand IGSF-11 could also offer benefits in certain situations by encouraging the development of regulatory T-cells, which play a crucial role, in preserving immune balance.

Studying how IGS11 impacts autoimmunity could offer ideas for treating diseases by targeting IGS-11 or its pathways to rebalance the immune system and potentially treat autoimmune disorders more effectively.

Cancer: Therapeutic Potential and Challenges

IGSF11 has become a figure, in the realm of cancer biology by playing a role in the evasion and advancement of tumors within the system domain. Tumor cells commonly utilize processes to avoid detection and elimination by the body’s immune defences. The presence of IGSF11 has been linked to types of cancers such, as lung cancer and melanoma.

Within the tumor microenvironment IGSF11 plays a role, in connecting tumor cells and immune cells which impacts the environment. For example, increased levels of IGS11 on tumor cells might boost their capacity to suppress T-cell activation leading to tolerance and supporting tumor development. This indicates that IGS11 could potentially be used as an indicator of outcomes in individuals, with cancer.

Exploring IGS11 as a target offers both advantages and obstacles in the realm of cancer treatment research. Understanding IGS11s impact, on types of cancer is essential for devisi​ng successful methods that harness its characteristics to boost immune responses, against tumors​.

Suitable ELISA Kits

• IGSF11 ELISA Kit
• Immunoglobulin Superfamily Member 11 ELISA Kit