Asprosin: A Novel Metabolic and Inflammatory Hormone

Molecular Structure and Origin

Asprosin is a C-terminal cleavage product of fibrillin-1, identified in 2016. This 140-amino acid protein is synthesized and secreted by white adipose tissue during fasting conditions. The protein’s structure includes:

• A C-terminal globular domain
• Multiple calcium-binding epidermal growth factor-like modules
• Specific proteolytic cleavage sites

Physiological Functions

Metabolic Regulation

Asprosin serves as a glucogenic hormone with several key functions:

Glucose Homeostasis: Stimulates hepatic glucose production, Activates G protein-cAMP-PKA pathway, Promotes glucose release from hepatocytes

Appetite Regulation: Crosses the blood-brain barrier, Activates orexigenic AgRP+ neurons, Stimulates appetite and food intake

Inflammatory Response

Asprosin demonstrates significant involvement in inflammatory processes:

• Promotes pro-inflammatory cytokine production
• Influences macrophage polarization
• Contributes to chronic inflammation in metabolic diseases

Clinical Significance and Disease Associations

Metabolic Disorders

Type 2 Diabetes: Elevated plasma asprosin levels, Correlation with insulin resistance, Potential therapeutic target

Obesity: Increased circulating levels, Association with body mass index, Impact on appetite regulation

Other Clinical Conditions

Cardiovascular Disease: Role in atherosclerosis development, Association with endothelial dysfunction, Potential biomarker for cardiac risk

Neonatal Progeroid Syndrome: Reduced asprosin levels, Growth retardation, Extreme leanness

Research Developments and Therapeutic Potential

Current Research Focus

Diagnostic Applications: Biomarker development, Disease progression monitoring, Risk assessment tools

Therapeutic Strategies: Anti-asprosin antibodies, Small molecule inhibitors, Receptor antagonists

Future Perspectives

Ongoing research explores:

• Novel drug development targeting asprosin
• Biomarker applications
• Role in other metabolic conditions
• Therapeutic potential in obesity treatment
• Impact on aging and longevity

Clinical Applications and Therapeutic Interventions

The therapeutic potential of asprosin modulation includes:

Metabolic Disease Treatment: Diabetes management, Obesity intervention, Appetite control

Anti-inflammatory Applications: Chronic inflammation reduction, Cardiovascular disease prevention, Metabolic syndrome management

Current clinical research focuses on developing:

• Asprosin antagonists
• Monoclonal antibodies
• Small molecule inhibitors
• Receptor modulators

Exploring the functions and control mechanisms of asprosin is essential, for crafting treatment approaches.

Suitable ELISA Kits

• Asprosin ELISA Kit