GET A QUOTE

TSH ELISA Kit (Rat)

  • Created on the 4 September, 2018.

INTENDED USE

Rat TSH ELISA kit is intended for analysing quantitative amounts of thyroid stimulating hormone (TSH, thyrotropin) present in rat serum. This assay has a minimum sensitivity detection limit of 0.1 ng/ml.

BACKGROUND

Thyroid stimulating hormone which can also be referred to as TSH or thyrotropin, plays a vital role in regulating the normal circulating levels of iodothyronines (T3 and T4). This is possible by controlling the production and secretion of TSH either by a negative feedback mechanism from the circulating levels of T3 and T4 or by the hypothalamic thyrotropin-releasing hormone (TRH). The mechanism process for controlling thyroid function in rats is found to be identical to that of humans and many other mammalian species. Due to the identical similarity between human and rat thyroid physiology, this makes the use of rats as an ideal model when evaluating the effects of new drugs on thyrometabolic status. Thyroid stimulating hormone ELISA kit can be used for the analysis and detection of many different diagnostic processes.

SENSITIVITY

The minimum sensitivity detection limit of thyrotropin (thyroid stimulating hormone) using current rat TSH ELISA kit is 0.1 ng/ml. The dynamic range for this assay is 2.5 – 80.0 ng/ml.

REFERENCES

  1. Effect of endogenous TSH on the in vitro responsiveness and binding of TSH in rat thyroid tissue. Endocr Res Commun. (1980) 7 (4): 205-19. Holmes S.D. and Field J.B.
  2. TSH binding proteins in rat and human serum. Acta Endocrinol (Copenh). (1987) 115 (4): 497-506. Spira O., et al.
  3. Discordant effects of thyrotropin (TSH)-releasing hormone on pre- and posttranslational regulation of TSH biosynthesis in rat pituitary. Endocrinology. (1986) 119 (1): 343-8. Lippman S.S., et al.
  4. Neurotensin regulation of TSH secretion in the rat. Biochem Biophys Res Commun. (1983) 113 (1): 248-54. Sheppard M.C., et al.
  5. Plasma and pituitary thyrotrophin (TSH) in severe and prolonged hypothyroidism, as studied in the rat. Clin Endocrinol (Oxf). (1977) 6 (1): 49-56. Cacicedo L., et al.
  6. Rapid proliferative response of rat thyroid gland to a single injection of TSH in vivo. J Endocrinol. (1989) 121 (1): 27-30. Bybee A. and Tuffery A.R.

ADDITIONAL INFORMATION

  • Full Name: Thyroid Stimulating Hormone ELISA Kit
  • Gene Name: TSH ELISA Kit
  • Reactivity: Rat
  • Sample Type: Serum
  • Sensitivity: 0.1 ng/ml

OTHER RELATED ELISA KITS

TESTIMONIALS arrow icon

Your secretory IgA ELISA gave good results and I was also really impressed with how quickly we received it.

L. Johnston
PhD Student / University of Glasgow

It is refreshing to know that you have a technical team that is very knowledgeable. I have already recommended your company to other researchers in our department.

Dr. P. Anderson
Lecturer / University College London (UCL)

I am a first time user and found that your instruction manual was very easy to follow. The insulin ELISA assay performed well and I was happy with the results that were generated.

J. Thomas
Senior Technician / Addenbrooke’s Hospital

I carried out a pilot study comparing the performance of many ELISA assay's from different suppliers and found your kits to be one of the better performers. We observed good linearity and tight replicates.

Dr. C. Davies
Lead Scientists / AstraZeneca

You are my first point of contact when I am looking to purchase ELISA. You have such an easy and simple system, yet it is very effective.

A. Shaw
Purchasing / University of Oxford