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Treponema Pallidum (Syphilis) IgG ELISA Kit

  • Created on the 25 September, 2017.

BACKGROUND

Treponema pallidum is a spirochaete bacterium which consists of many sub-species and these are responsible for causing many treponemal diseases for example syphilis, pinta, bejel or yaws. They are helically coiled microorganism which are 0.1–0.2 µm (width) and 6–15 µm (long), also consisting of a cytoplasmic and an outer membrane. Currently, there are 4 known sub-species Treponema pallidum pallidum (causes syphilis), T. p. carateum (causes pinta), T. p. endemicum (causes endemic syphilis or bejel) and T. p. pertenue (causes yaws). T. p. pallidum is a motile spirochaete which is usually acquired as a results of sexual contact, it is able to enter the host through columnar epithelium or breaches in squamous. This can be transmitted to the fetus via the transplacental passage during the last stages of pregnancy (known as congenital syphilis). Clinically syphilis is difficult to diagnose early, its confirmation tends to be either through blood tests or by using microscopy methods in order to make a direct visual inspection. However, it is not possible to distinguish the different stages of the disease using these diagnostic tests.

INTENDED USE

Human syphilis IgG ELISA kit is intended for detecting semi-quantitative and qualitative levels of human IgG class of antibodies against treponema pallidum (syphilis) using serum. The diagnostic sensitivity for this assay is defined as the probability of scoring positive in the presence of the specific analyte.

SENSITIVITY

The diagnostic sensitivity of human treponema pallidum (syphilis) IgG using this human syphilis-IgG ELISA kit is the probability of scoring positive. The dynamic assay range for this kit was to a specific cut-off point.

REFERENCES

  1. Establishment and Evaluation of a One-Step Microplate Chemiluminescence Immunoassay to Detect IgG Antibody Against Treponema Pallidum. J Clin Lab Anal. (2015) 29 (6): 493-7. Liu L., et al.
  2. Treponema pallidum-specific antibody expression for the diagnosis of different stages of syphilis. Chin Med J (Engl). (2013) 126 (2): 206-10. Sun R., et al.
  3. Changes of serum IgG antibody reactivity to protein antigens of Treponema pallidumin syphilis patients after treatment. J Korean Med Sci. (1989) 4 (2): 63-9. Kim D.K., et al.
  4. Ig class and IgG subclass responses to Treponema pallidumin patients with syphilis. J Clin Immunol. (1988) 8 (2): 128-39. Baughn R.E., et al.
  5. Use of the Treponema pallidum-specific captia syphilis IgG assay in conjunction with the rapid plasma reagin to test for syphilis. J Clin Microbiol. (1997) 35 (5): 1141-3. Reisner B.S., et al.

ADDITIONAL INFORMATION

  • Full Name: Treponema Pallidum (Syphilis) IgG ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum
  • Sensitivity: Cut-Off

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