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Tissue Transglutaminase Ab IgG ELISA Kit

  • Created on the 29 June, 2017.

BACKGROUND

TG2 or tTG which is short for tissue transglutaminase is a member of the γ-glutamyltransferases family and is a 78 kDa, calcium-dependent enzyme. It is vital for many functions such as wound healing, extracellular matrix development and apoptosis. tTG is multifunctional and is responsible for catalysing the crosslinking of proteins through epsilon-lysine isopeptide bonds. It has been associated with celiac disease, which is caused by dietary consumption of gluten and this can lead to a number of different pathological immune responses. tTG is fundamental in processes such as inflammation and tumor biology, it is also found in many neurodegenerative disorders for example Parkinson, Alzheimer and Huntington diseases.

INTENDED USE

Human tissue transglutaminase IgG ELISA kit can be used for determining in-vitro quantitative levels of IgG class autoantibodies to tissue transglutaminase (TG2, tTG) in human serum or plasma. This assay has a minimum analytical sensitivity limit of 1.0 U/ml.

SENSITIVITY

The minimum detection sensitivity level of human tTG /TG2 IgG class autoantibodies using this human tissue transglutaminase IgG ELISA kit was 1.0 U/ml. The dynamic assay range for this kit is 5.0 – 200.0 U/ml.

REFERENCES

  1. Role of human-tissue transglutaminase IgG and anti-gliadin IgG antibodies in the diagnosis of coeliac disease in patients with selective immunoglobulin A deficiency. Dig Liver Dis. (2004) 36 (11): 730-4. Lenhardt A., et al.
  2. IgG anti-tTG responses in different autoimmune conditions differ in their epitope targets and subclass usage. Mol Immunol. (2015) 67 (2 Pt B): 369-76. Comerford R., et al.
  3. A rare case of Addison’s disease, hepatitis, thyreoiditis, positive IgG anti-tissue transglutaminase antibodies and partial IgA deficiency. Cent Eur J Immunol. (2016) 41 (2): 217-20. Baleva M.P., et al.

ADDITIONAL INFORMATION

  • Full Name: Tissue Transglutaminase Ab IgG ELISA Kit
  • Reactivity: Human
  • Sample Type: Plasma, Serum
  • Sensitivity: 1.0 U/ml

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