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Tissue Transglutaminase Ab IgA ELISA Kit

  • Created on the 29 June, 2017.

INTENDED USE

Human tissue transglutaminase IgA ELISA kit is a procedure intended for in-vitro quantitative measurement of IgA class autoantibodies direct to tissue transglutaminase (tTG, TG2) in human serum and plasma samples. This assay has a minimum analytical sensitivity limit of 1.0 U/ml.

BACKGROUND

Tissue transglutaminase which can also referred to as tTG and TG2, is a calcium-dependent enzyme which is 78 kDa and belongs to the γ-glutamyltransferases family. It is a multi-functional enzyme which can catalyse the crosslinking of proteins via epsilon-lysine isopeptide bonds. It has been implicated in a number of different functions which can include apoptosis, extracellular matrix development and wound healing. tTG is however, best known for its association with celiac disease, this is an illness where dietary gluten consumption can lead to pathological immune responses causing inflammation of the small intestine. tTG is also found to be instrumental in a number of neurodegenerative disorders such as Alzheimer, Huntington and Parkinson diseases. Recent studies have indicated that it may paly important role in tumor biology and inflammation. The following tissue transglutaminase IgA ELISA kit is designed to be used for many different diagnostic applications.

SENSITIVITY

The minimum detection sensitivity level of tissue transglutaminase (tTG or TG2) IgA autoantibodies using current human tissue transglutaminase-IgA ELISA kit was 1.0 U/ml. The dynamic range for this assay is 5.0 – 200.0 U/ml.

REFERENCES

  1. IgA anti-tissue transglutaminase: setting the stage for coeliac disease screening. Eur J Gastroenterol Hepatol. (2001) 13 (6): 635-7. Review. Schuppan D. and Hahn E.G.
  2. Overview of biomarkers for diagnosis and monitoring of celiac disease. Adv Clin Chem. (2015) 68: 1-55. Review. Brusca I.
  3. Anti-tissue transglutaminase antibodies and their role in the investigation of coeliac disease. Ann Clin Biochem. (2006) 43 (Pt 2): 105-17. Review. Hill P.G. and McMillan S.A.

ADDITIONAL INFORMATION

  • Full Name: Tissue Transglutaminase Ab IgA ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum, Plasma
  • Sensitivity: 1.0 U/ml

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