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Thyroid Stimulating Hormone (TSH) ELISA Kit

  • Created on the 2 February, 2017.

BACKGROUND

Thyroid stimulating hormone (TSH) which is also sometimes called thyrotropin is a glycoprotein hormone that has a molecular weight of 28,000 Daltons and is secreted by the pituitary gland. The function of TSH is to regulate the synthesis and release of T3 and T4 by the thyroid gland. Thyroid stimulating hormone is composed of alpha and beta subunits, the alpha subunits are similar alpha subunits found in LH, FSH and hCG glycoprotein hormones alpha subunits whereas the beta is more specific and is different from one hormone to another. One of the most important maker in the diagnosis of thyroid disorders is the measurement of serum TSH levels, where elevated concentrations of TSH (thyrotropin) can be a good indicator for overt primary hypothyroidism and a decrease in the thyroid reserve levels. Additionally, determining the levels of TSH is equally helpful in differentiating secondary and tertiary hypothyroidism (hypothalamic) from the primary thyroid disease. The advent of immunoassays has provided laboratories with sufficient sensitivity to be able to differentiate hyperthyroidism from euthyroid population. This current ELISA kit is a second-generation assay that is able to provide a tool that can offer a means for discriminating the hyperthyroid-euthyroid range.

INTENDED USE

Thyroid stimulating hormone ELISA kit is a reliable quantitative procedure for measuring TSH (thyrotropin) in human serum samples. This assay has a sensitivity detection limit of 0.06 mIU/l.

SENSITIVITY

The minimum sensitivity detection limit for TSH (thyrotropin) using this TSH ELISA kit was approximately 0.06 mIU/l. The dynamic assay range for this kit is between 0.25 – 15 mIU/l.

REFERENCES

  1. Determination of Protein Bound Iodine. Joumal Biological Chemistry (1948) 173, 175. Barker, S.B.
  2. A Radioimmunoassay of Thyrotropin. J. Clinical Endocrinol. (1971) 33, 865 (1971). Chopra, I.J., Solomon, D.H., and Ho, R.S.
  3. Effects of Drugs on Clinical Laboratory Tests. Clinical Chemistry (1975) 21, 3660. Young, D.S., Pestaner, L.C., and Gilberman, U.

ADDITIONAL INFORMATION

  • Full Name: Thyroid Stimulating Hormone (TSH) ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum
  • Sensitivity: 0.06 mIU/l

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