- Created on the 2 February, 2017.
Thyroid peroxidase-Ab ELISA kit is a reliable quantitative procedure for measuring thyroid peroxidase antibody (TPO-Ab) in human serum and plasma. This assay has a detection sensitivity limit of 5 IU/ml.
Thyroid peroxidase (TPO) is a membrane-bound hemoprotein which has a molecular weight of nearly 100 kDa. It is essential for thyroid hormone synthesis because this microsomal antigen is an integral membrane protein of the microsomes. Persisting inhibition of TPO activity by specific autoantibodies (Anti-TPO Abs) has been found to cause a decrease in the synthesis of thyroid hormones and thus lead to hypothyroidism. Also, high autoantibodies titers to TPO are frequently discovered in patients that have myxedema (atrophic thyroiditis), Hashimoto’s disease (goitrous thyroiditis) and Graves’ disease. They may be predictive in asymptomatic individuals who are diagnosed for hypothyroidism. Especially at the end of pregnancy, where the determination of thyroid antibodies can be a helpful diagnostic tool to diagnose the early onset of post-partum hypothyroidism.
The minimum sensitivity detection limit of TPO antibody using current thyroid peroxidase-Ab ELISA kit was approximately 5 IU/ml. The dynamic range for this assay is between 33 – 3,000 IU/ml.
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- Full Name: Thyroid Peroxidase Antibody (TPO-Ab) ELISA Kit
- Reactivity: Human
- Sample Type: Serum, Plasma
- Sensitivity: 5 IU/ml