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Thyroglobulin (hTG) ELISA Kit

  • Created on the 2 February, 2017.

BACKGROUND

Human thyroglobulin (hTG) is a multiple glycosylated, water soluble iodoprotein that has a molecular weight of approx. 660,000 Daltons shared by two identical subunits. It is synthesised in the thyrocytes of the thyroid gland and then later secreted into the lumen of the thyroid follicles, which eventually becomes the precursors of the T3 and T4 thyroid hormones. The circulating levels of hTG are found to be increased in several thyroid disorders such as differentiated thyroid carcinoma, non-toxic goiter, thyroiditis and hyperthyroidism. The use of circulating human thyroglobulin (hTG) as an indicator of recurrent tumors (metastasis marker) has well established clinical values for example the increase of thyroglobulinaemia is a good indicator that further analysis is needed in order to confirm the diagnosis. A main application for the thyroglobulin determination is the post-surgical monitoring of patients with differentiated thyroid carcinoma. Also, its measurement is a special prognostic value to Graves` disease patients who are undergoing therapy.

INTENDED USE

Thyroglobulin ELISA kit is a reliable quantitative procedure for measuring thyroglobulin (hTG) in human serum or plasma. The lowest sensitivity detection limit of this assay is 1.0 ng/ml.

SENSITIVITY

The minimum detectable sensitivity limit of thyroglobulin (hTG) using this thyroglobulin ELISA kit was approximately 1.0 ng/ml. The functional sensitivity of this kit is determined to be 3.75 ng/ml.

REFERENCES

  1. J. Nuclear Medicine (1991) 32 (3), 395 – 398. Ruiz-Garcia J., et al.
  2. J. Endocrinol. Invest. (1980) 3, 283 – 292. Pacini F., et al.
  3. J. Endocrinol. Invest. (1990) 13, 737 – 742. Rubello D., et al.
  4. J. Medicine. New Series (1986) 59 (229), 429 – 433. Sheppard M. C.
  5. La Presse Médicale (1990) 19 (28), 1309 – 1312. Tourniaire J., et al.
  6. Diagn. Oncol. (1991) 1, 194 – 196. Pacini F., et al.

ADDITIONAL INFORMATION

  • Full Name: Thyroglobulin (hTG) ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum, Plasma
  • Sensitivity:  1.0 ng/ml

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