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TBEV IgM ELISA Kit

  • Created on the 22 September, 2017.

BACKGROUND

Tick-borne encephalitis virus (TBEV) is a pathogen which can be inactivated by ether or sodium desoxycholate and it is a single stranded RNA. It belongs the genus Flavivirus, other family member are Alkhurma virus, Kyasanur forest disease virus, Louping ill virus and Omsk hemorrhagic fever virus. The standard incubation period for a TBE infection can be between 7-14 days and it is found most frequently in rural areas during the summer months. The virus is able to replicate within the cytoplasma of the cells which it infects. The diagnosis of a fresh infection is usually carried out in the laboratory by analysing the levels of specific IgM antibodies, the measurement of IgG levels can be useful to follow the course of the infection or to measure the immune status after active vaccination protection.

INTENDED USE

Human TBEV-IgM ELISA kit can be used for determining in-vitro quantitative levels of human IgM antibodies to TBEV (FSME) virus in serum or plasma. This assay has a minimum analytical sensitivity limit of 1.37 U/ml.

SENSITIVITY

The minimum detection sensitivity level of human tick-borne encephalitis virus IgM using this human TBEV-IgM ELISA kit was 1.37 U/ml. The dynamic assay range for this kit is 10.0 – 1,000.0 U/ml.

REFERENCES

  1. Serological diagnosis of acute tick-borne encephalitis by demonstration of antibodies of the IgM class. J Med Virol. (1981) 7 (1): 41-50. Roggendorf M., et al.
  2. Test based on subtype-specific μ-capture IgM immunoassay can distinguish between infections of European and Siberian subtypes of tick-borne encephalitis virus. J Clin Virol. (2015) 73: 81-83. Levanov L., et al.
  3. Vaccine failures after active immunisation against tick-borne encephalitis. Vaccine. (2010) 28 (16): 2827-31. Andersson C.R., et al.
  4. Tick-borne viruses: a review from the perspective of therapeutic approaches. Ticks Tick Borne Dis. (2014) 5 (5): 457-65. Review. Lani R., et al.

 ADDITIONAL INFORMATION

  • Full Name: TBEV IgM ELISA Kit
  • Reactivity: Human
  • Sample Type: Plasma, Serum
  • Sensitivity: 1.37 U/ml

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