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SS-A Ab ELISA Kit

  • Created on the 29 June, 2017.

BACKGROUND

Sjögren syndrome type A antigen (SS-A) are autoantibodies that are regarded as antinuclear antibody (ANA) which essentially targeting the nucleic acids in the cell cytoplasm rather than the cell nucleus. This is in contrast to standard ANAs which tend to target nucleic acids in the cell nucleus, for this reason individuals having ANA-negative systemic lupus are found to frequently have SSA antibodies. SS-A antibodies are vital diagnostic markers which can be used to diagnose many autoimmune diseases for example SLE, PSS and polymyositis. Clinical studies have also indicated that over 70 percent patients with SSA antibodies also display rheumatoid factor (RF). This is an autoantibody that can target immunoglobulin G, which is present in rheumatoid arthritis (RA), Sjogren’s syndrome scleroderma and polymyositis.

INTENDED USE

Human SS-A ELISA kit is a method intended for in-vitro quantitative detection of IgG autoantibodies to Sjögren syndrome type A (SS-A, anti-SSA) in human serum or plasma. This assay has a minimum analytical sensitivity limit of 1.0 U/ml.

SENSITIVITY

The minimum detection sensitivity level of human Sjögren syndrome type A (anti-SSA, SSA-A) IgG autoantibodies using this human SS-A ELISA kit was 1.0 U/ml. The dynamic assay range for this kit is 12.5 – 200.0 U/ml.

REFERENCES

  1. A comprehensive review of autoantibodies in primary Sjögren’s syndrome: clinical phenotypes and regulatory mechanisms. J Autoimmun. (2014) 51: 67-74. Review. Kyriakidis N.C., et al.
  2. Biologic treatment in Sjögren’s syndrome. Rheumatology (Oxford). (2015) 54 (2): 219-30. Review. Sada P.R., et al.
  3. Clinical characteristics of RA patients with secondary SS and association with joint damage. Rheumatology (Oxford). (2015) 54 (5): 816-20. Brown L.E., et al.
  4. SS-A (Ro) antibody in random mother-infant pairs. J Clin Pathol. (1985) 38 (1): 73-5. Calmes M. and Bartholomew B.A.
  5. Anti-Ro(SSA) antibodies in patients with rheumatoid arthritis–a possible marker for gold induced side effects. J Rheumatol. (1994) 21 (6): 1040-2. Tishler M., et al.

ADDITIONAL INFORMATION

  • Full Name: SS-A Ab ELISA Kit
  • Reactivity: Human
  • Sample Type: Plasma, Serum
  • Sensitivity: 1.0 U/ml

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