Serotonin Research ELISA Kit

BACKGROUND

Serotonin (also called 5-hydroxytryptamine), is a biogenic amine that is formed for tryptophan metabolism and it can be metabolised to 5-HIAA by the liver. Approx. 80% serotonin that is present in humans is found in the gastrointestinal tract (GI tract) and is located on enterochromaffin cells. One of its main function here is to regulate the movement of the gut. There is also evidence that it can be synthesised by serotonergic neurons within the central nervous system.

Serotonin is an example of an inhibitory neurotransmitter, mainly found in the gastrointestinal tract, central nervous system and the platelets. It is considered as a natural mood stabiliser and the chemical which is responsible for helping in the process of eating, digesting and sleeping. It is also found to help reduce depression, heal wounds, maintain bone health, stimulate nausea and regulate anxiety. Pharmacological antidepressants can be used in order to modulate serotonin that can be present at the synapses junction.

INTENDED USE

Serotonin ELISA kit can be used for measuring in vitro quantitative levels of serotonin (5-hydroxytryptamine) human tissue homogenates, dialysates and many other biological sample types. This assay has a minimum detection limit of 0.005 ng/ml.

SENSITIVITY

The minimum detection sensitivity level of serotonin (5-hydroxytryptamine) using this human serotonin ELISA kit was approximately 0.005 ng/ml. The dynamic assay range for this kit is 0.015 – 2.5 ng/ml.

REFERENCES

1. Serotonin regulates performance nonmonotonically in a spatial working memory network. Cereb Cortex. (2014) 24 (9): 2449-63. Cano-Colino M., et al.
2. Oxidation of high doses of serotonin favors lipid accumulation in mouse and human fat cells. Mol Nutr Food Res. (2013) 57 (6): 1089-99. Grès S., et al.
3. Serotonin and cancer: what is the link? Curr Mol Med. (2015) 15 (1): 62-77. Review. Sarrouilhe D., et al.
4. Future directions for serotonin and antidepressants. ACS Chem Neurosci. (2013) 4 (1): 5-8. Artigas F.
5. The role of serotonin in memory: interactions with neurotransmitters and downstream signaling. Exp Brain Res. (2014) 232 (3): 723-38. Review. Seyedabadi M., et al.
6. Changes in markers of brain serotonin activity in response to chronic exercise in senior men. Appl Physiol Nutr Metab. (2014) 39 (11): 1250-6. Melancon M.O., et al.

ADDITIONAL INFORMATION

• Full Name: Serotonin Research ELISA Kit
• Reactivity: Human
• Sample Type: Tissue Homogenate, Dialysate, Other Biological Samples
• Sensitivity: 0.005 ng/ml

OTHER RELATED ELISA KITS

• Histamine Research ELISA Kit
• Tryptophan ELISA Kit
• Chromogranin A ELISA Kit