- Created on the 29 June, 2017.
Topoisomerase 1 (also called Scl-70) is a nucleolar and nuclear enzyme which is regarded as being specific for systemic sclerosis (scleroderma) and it can be found in over 60% of patients possessing this connective tissue disease. Scleroderma has been associated with a number of autoantibodies, each of which can be helpful in diagnosing the affected patients and in determining the prognosis. Anti-Scl-70 and anti-centromere antibodies (ACA) are particularly useful in distinguishing patients having systemic sclerosis (SSc), these antibodies are associated with more severe scleroderma disease.
Human Scl-70 ELISA kit is designed for determining in-vitro quantitative concentrations of IgG autoantibodies to topoisomerase 1 (Scl-70) in human plasma and serum. This assay has a minimum analytical sensitivity limit of 1.0 U/ml.
The minimum detection sensitivity level of human anti-topoisomerase 1 (topo-1, anti-Scl-70) IgG autoantibodies using this human Scl-70 ELISA kit was 1.0 U/ml. The dynamic assay range for this kit is 12.5 – 200.0 U/ml.
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- Full Name: Scl-70 Ab ELISA Kit
- Reactivity: Human
- Sample Type: Serum, Plasma
- Sensitivity: 1.0 U/ml