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Rubella IgG ELISA Kit

  • Created on the 22 August, 2017.

BACKGROUND

Rubella virus belongs to the family Togaviridae, it is between 40-80 nm, single-stranded, positive-sense, spherical RNA virus which contains hemagglutinin surface projections. It is made up of three major structural polypeptides and is the only serotype which has been identified. Rubella (also known as German measles) is a common mild disease that can be characterised by a rash, it can be transmitted through direct or droplet contact with respiratory secretions. When rubella virus infects susceptible women during the early of pregnancy, it can be transmitted to the fetus which could lead to possible birth defects. In general, it is found to affects children and adolescents throughout the worldwide, it can also affect young adults. Laboratory methods which can be used to detecting rubella include ELISA assays, hemagglutination inhibition test (HIT) and hemolysis-in-gel test. The IgG test is helpful in determining immunity, whereas virus-specific IgM antibodies detection is crucial in measuring a fresh infection.

INTENDED USE

Human rubella-IgG ELISA kit is a method intended for analysing in-vitro quantitative levels of human IgG antibodies against rubellavirus in samples of serum and plasma. This assay has a minimum analytical sensitivity limit of 0.38 IU/ml.

SENSITIVITY

The minimum detection sensitivity level of human rubella virus IgG using this human rubella-IgG ELISA kit was 0.38 IU/ml. The dynamic assay range for this kit is 0 – 500 IU/ml.

REFERENCES

  1. Investigation into low-level anti-rubellavirus IgG results reported by commercial immunoassays. Clin Vaccine Immunol. (2013) 20 (2): 255-61. Dimech W., et al.
  2. Standardization of Assays That Detect Anti-Rubella Virus IgG Antibodies. Clin Microbiol Rev. (2016) 29 (1): 163-74. Review. Dimech W., et al.
  3. Prevalence of rubella-specific IgG antibodies in unimmunized young female population. J Family Med Prim Care. (2016) 5 (3): 658-662. Thayyil J., et al.
  4. Maturation of rubella IgG avidity over time after acute rubella infection. Clin Diagn Virol. (1997) 8 (2): 105-11. Böttiger B. and Jensen I.P.
  5. Placental transfer of rubella-specific IgG in fullterm and preterm newborns. Int J Gynaecol Obstet. (2003) 81 (2): 157-62. Doroudchi M., et al.

ADDITIONAL INFORMATION

  • Full Name: Rubella IgG ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum, Plasma
  • Sensitivity: 0.38 IU/ml

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