GET A QUOTE

Rheumatoid Factor IgM ELISA Kit

  • Created on the 16 June, 2017.

INTENDED USE

Human rheumatoid factor IgM ELISA kit is designed for detecting in-vitro quantitative amounts of IgM antibodies to rheumatoid factor (RF, RF-IgM, anti-rheumatoid factor-IgM) in human serum or plasma. This assay has a minimum analytical sensitivity limit of 1.0 IU/ml.

BACKGROUND

Rheumatoid factor (RF) was first discovered in rheumatoid arthritis, it is mainly found as the isotype IgM but it can also be in IgA, IgD, IgE and IgG form. RF is found as an antibody directed against the Fc portion of IgG, however, there are many different RFs proteins which are able to attach to specific sections of the IgG-Fc molecule. Rheumatoid factors are useful diagnostic markers for individuals that are suspect for rheumatoid arthritis or any other related autoimmune conditions.

SENSITIVITY

The minimum detection sensitivity level of human anti-rheumatoid factor IgM (RF IgM) using current human rheumatoid factor-IgM ELISA kit was 1.0 U/ml. The dynamic range for this assay is 15.0 – 500.0 IU/ml.

REFERENCES

  1. Mesangial glomerulopathy and IgM rheumatoid factor in rheumatoid arthritis. Nephron. (1989) 51 (1): 107-11. Pollet S., et al.
  2. Heterogeneity of IgM/IgG cryocomplexes: immunological-clinical correlation. J Rheumatol. (1975) 2 (2): 225-40. MacKechnie H.L., et al.
  3. CD5 negative IGM rheumatoid factor B cells in B-chronic lymphocytic leukemia and benign mixed cryoglobulinemia. Leuk Lymphoma. (1992) 7 (1-2): 55-62. Review. Martin T. and Pasquali J.L.
  4. [Immunological and serological tests for diagnosis of rheumatoid arthritis: IgM-RF]. Nihon Rinsho. (2005) 63 Suppl 1: 318-21. Review. Japanese. Ishizuka S., et al.
  5. Rheumatoid factors: good or bad for you? Int Arch Allergy Immunol. (2005) 138 (2): 180-8. Review. Nowak U.M. and Newkirk M.M.
  6. IgM paraproteins. J Clin Pathol Suppl (Assoc Clin Pathol). (1975) 6: 54-64. Review. Hobbs J.R., et al.

ADDITIONAL INFORMATION

  • Full Name: Rheumatoid Factor IgM ELISA Kit
  • Reactivity: Human
  • Sample Type: Plasma, Serum
  • Sensitivity: 1.0 IU/ml

OTHER RELATED ELISA KITS

TESTIMONIALS arrow icon

Your secretory IgA ELISA gave good results and I was also really impressed with how quickly we received it.

L. Johnston
PhD Student / University of Glasgow

It is refreshing to know that you have a technical team that is very knowledgeable. I have already recommended your company to other researchers in our department.

Dr. P. Anderson
Lecturer / University College London (UCL)

I am a first time user and found that your instruction manual was very easy to follow. The insulin ELISA assay performed well and I was happy with the results that were generated.

J. Thomas
Senior Technician / Addenbrooke’s Hospital

I carried out a pilot study comparing the performance of many ELISA assay's from different suppliers and found your kits to be one of the better performers. We observed good linearity and tight replicates.

Dr. C. Davies
Lead Scientists / AstraZeneca

You are my first point of contact when I am looking to purchase ELISA. You have such an easy and simple system, yet it is very effective.

A. Shaw
Purchasing / University of Oxford