- Created on the 16 June, 2017.
Human rheumatoid factor IgA ELISA kit is intended for detecting in-vitro quantitative levels of IgA antibody to rheumatoid factor (RF, RF-IgA, anti-rheumatoid factor-IgA) using human plasma or serum samples. This assay has a minimum analytical sensitivity limit of 1.0 U/ml.
Rheumatoid factor (RF) is an auto-antibody that is produced by the immune system which can attack healthy tissues in the body, it was first identified in rheumatoid arthritis. Although it is predominantly encountered as IgM, rheumatoid factor be found as any of the immunoglobulins isotypes for example IgM, IgG, IgA, IgE and IgD. It is essentially characterised as an antibody against the Fc portion of IgG, there is evidence that different RFs have the ability to recognise different parts of the IgG-Fc. Rheumatoid factor and IgG are able to join and form immune complexes which are contributing to the disease process. RF is most often used to evaluate patients that are suspected of having a form of arthritis and with the combination of signs or symptoms, it can be used for diagnosis and the disease prognosis.
The minimum detection sensitivity level of human anti-rheumatoid factor IgA (RF-IgA) using current human rheumatoid factor-IgA ELISA kit was 1.0 U/ml. The dynamic range for this assay is 15.0 – 500.0 U/ml.
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- Full Name: Rheumatoid Factor IgA ELISA Kit
- Reactivity: Human
- Sample Type: Plasma, Serum
- Sensitivity: 1.0 U/ml