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Rheumatoid Factor IgA ELISA Kit

  • Created on the 16 June, 2017.

BACKGROUND

Rheumatoid factor (RF) is an autoantibody that is produced by the immune system which can attack healthy tissues in the body, it was first identified in rheumatoid arthritis. Although it is predominantly encountered as IgM, rheumatoid factor be found as any of the immunoglobulins isotypes for example IgM, IgG, IgA, IgE and IgD. It is essentially characterised as an antibody against the Fc portion of IgG, there is evidence that different RFs have the ability to recognise different parts of the IgG-Fc. Rheumatoid factor and IgG are able to join and form immune complexes which are contributing to the disease process. RF is most often used to evaluate patients that are suspected of having a form of arthritis and with the combination of signs or symptoms, it can be used for diagnosis and the disease prognosis.

INTENDED USE

Human rheumatoid factor-IgA ELISA kit is intended for detecting in-vitro quantitative levels of IgA rheumatoid factor (RF) using human plasma or serum samples. This assay has a minimum analytical sensitivity limit of 1.0 U/ml.

SENSITIVITY

The minimum detection sensitivity level of human rheumatoid factor IgA (RF IgA) using this human rheumatoid factor-IgA ELISA kit was 1.0 U/ml. The dynamic assay range for this kit is 15.0 – 500.0 U/ml.

REFERENCES

  1. What about IgA rheumatoid factor in rheumatoid arthritis? Ann Rheum Dis. (1998) 57 (1): 63-4. Review. Jónsson T. and Valdimarsson H.
  2. Rheumatoid factors and anticyclic citrullinated peptide antibodies in pediatric rheumatology. Curr Rheumatol Rep. (2008) 10 (2): 156-63. Review. Syed R.H., et al.
  3. IgA in Sjögren’s syndrome. Clin Exp Rheumatol. (1994) 12 (5): 543-51. Review. Levy Y., et al.
  4. Clinical and biological polymorphism of rheumatoid arthritis. Clin Exp Rheumatol. (1994) 12 Suppl 11: S59-61. Review. Sany J.
  5. IgA rheumatoid factor as predictor of disease activity. Scand J Rheumatol Suppl. (1988) 75: 233-7. Review. Teitsson I.

ADDITIONAL INFORMATION

  • Full Name: Rheumatoid Factor IgA ELISA Kit
  • Reactivity: Human
  • Sample Type: Plasma, Serum
  • Sensitivity: 1.0 U/ml

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