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Prothrombin Screen ELISA Kit

  • Created on the 16 June, 2017.

BACKGROUND

Prothrombin is a carbohydrate-protein compound which is transformed to thrombin using the enzyme prothrombinase, thrombin is then responsible for transforming fibrinogen into fibrin. Platelets and fibrin can cause the formation clots, a process known as coagulation and this is important during bleeding. A deficiency in prothrombin which is known as hypoprothrombinemia is defined by its prolonged tendency to bleeding.

INTENDED USE

Human prothrombin ELISA kit is useful for sceening in-vitro quantitative concentrations of IgG, IgA and IgM autoantibodies to prothrombin in human serum or plasma. This assay has a minimum analytical sensitivity limit of 1.0 U/ml.

SENSITIVITY

The minimum detection sensitivity level of human prothrombin IgM, IgG and IgA autoantibodies using this human prothrombin ELISA kit was 1.0 U/ml. The dynamic assay range for this kit is 6.3 – 100.0 U/ml.

REFERENCES

  1. Mixing studies for abnormal coagulation screen – the current trend. Clin Chem Lab Med. (2017) 55 (3): e54-e55. Mohammad E. and Thachil J.
  2. IgG, IgA, IgM, and IgD antiglobulins in juvenile rheumatoid arthritis. Ann Rheum Dis. (1974) 33 (1): 32-4. Florin-Christensen A., et al.
  3. Utility of antiphosphatidylserine/prothrombin and IgA antiphospholipid assays in systemic lupus erythematosus. J Rheumatol. (2013) 40 (3): 282-6. Akhter E., et al.
  4. Selected autoantibodies and normal-tension glaucoma. Med Sci Monit. (2014) 20: 1201-9. Skonieczna K., et al.

ADDITIONAL INFORMATION

  • Full Name: Prothrombin Screen ELISA Kit
  • Reactivity: Human
  • Sample Type: Plasma, Serum
  • Sensitivity: 0 U/ml

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