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N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) ELISA Kit

  • Created on the 16 May, 2017.

BACKGROUND

N-terminal prohormone of brain natriuretic peptide (also called NT-proBNP and BNPT) is an inactive protein which is released as a result of cleaving the N-terminal 76 amino acid fragment from brain natriuretic peptide. Both the bioactive BNP and the inactive NT-proBNP have been useful in the diagnosis and management of heart failure. Their concentrations in blood are vital for the diagnosis and screening of acute congestive heart failure and can help to establish the prognosis in heart failure, since both of these marker are often elevated in patients with the worse outcome. The plasma levels are also increased in patients with associated coronary artery disease, myocardial ischemia, symptomatic or asymptomatic left ventricular dysfunction. Some of the main advantages NT-proBNP have over BNP is that it possesses superior stability, higher circulating levels and a relatively smaller amount of serum is needed to carry out a measurement.

INTENDED USE

Human NT-proBNP ELISA kit can be used for measuring in vitro quantitative levels of N-terminal pro-brain natriuretic peptide (BNPT, NT-proBNP) in human cell culture supernatant, plasma, cell lysates, serum and many other biological fluids. This assay has a minimum sensitivity limit of 0.51 ng/L.

SENSITIVITY

The minimum detection sensitivity level of human NT-proBNP using this human N-terminal pro-brain natriuretic peptide ELISA kit was 0.51 ng/mL. The dynamic assay range for this kit is 1.0 – 380.0 ng/L.

REFERENCES

  1. BNP and NT-proBNP as prognostic markers in persons with acute decompensated heart failure: a systematic review. Heart Fail Rev. (2014) 19 (4): 453-70. Review. Santaguida P.L., et al.
  2. The predictive value of plasma biomarkers in discharged heart failure patients: role of plasma NT-proBNP. Minerva Cardioangiol. (2016) 64 (2): 157-64. Review. Leto L., et al.
  3. Amino-Terminal Pro-B-Type Natriuretic Peptide for Diagnosis and Prognosis in Patients With Renal Dysfunction: A Systematic Review and Meta-Analysis. JACC Heart Fail. (2015) 3 (12): 977-89. Review. Schaub J.A., et al.
  4. The potential role of natriuretic peptides and other biomarkers in heart failure diagnosis, prognosis and management. Expert Rev Cardiovasc Ther. (2015) 13 (9): 1017-30. Review. Ibrahim N. and Januzzi J.L.
  5. N-terminal pro-B-type natriuretic peptide variability in stable dialysis patients. Clin J Am Soc Nephrol. (2015) 10 (4): 620-9. Fahim M.A. et al.

ADDITIONAL INFORMATION

  • Full Name: N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) ELISA Kit
  • Reactivity: Human
  • Sample Type: Cell Lysates, Cell Culture Supernatant, Plasma, Serum, Other Biological Fluids
  • Sensitivity: 0.51 ng/L

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