Macrophage Colony-Stimulating Factor (M-CSF) ELISA Kit
- Created on the 7 February, 2017.
INTENDED USE
Human M-CSF ELISA kit is a reliable quantitative procedure for measuring macrophage colony-stimulating factor (MCSF or M-CSF) in human serum, plasma (heparin, EDTA), cell culture supernatant, saliva, tissue lysates, body fluids and urine. This assay t has a minimum sensitivity detection limit of < 1.0 pg/ml.
BACKGROUND
Macrophage colony-stimulating factor (MCSF, M-CSF) which is also known as colony stimulating factor 1 (CSF1) is a hematopoietic growth factor that is important for the proliferation, differentiation, and survival of macrophages, bone marrow progenitor cells and monocytes. M-CSF are able to affect monocytes or macrophages in many ways including increasing the cytotoxicity of tumour cell and increasing the stimulation of chemotactic or phagocytic activity. Also, through the interaction with its membrane receptor it can modulate the proliferation of earlier hematopoietic progenitors, resulting in influencing a number of physiological processes that are involved in metabolism, fertility, pregnancy and immunology. There is evidence that eukaryotic cells are able to produce M-CSF in order to combat any intercellular viral infection. It is also known to play a crucial role in renal pathology that includes chronic renal failure and acute kidney injury. The following M-CSF ELISA kit can be used for a vast range of clinical applications.
SENSITIVITY
The minimum sensitivity detection limit of macrophage colony-stimulating factor (MCSF) using current M-CSF ELISA kit was approximately < 1.0 pg/ml. The dynamic range for this assay is 15.6 – 1000.0 pg/ml.
REFERENCES
- Human CSF-1: gene structure and alternative splicing of mRNA precursors. EMBO J. (1987) 6: 2693-2698. Ladner, M. B., et al.
- Apparent role of the macrophage growth factor, CSF-1, in placental development. Nature (1987) 330: 484-486. Pollard, J. W., et al.
ADDITIONAL INFORMATION
- Full Name: Macrophage Colony-Stimulating Factor (M-CSF) ELISA Kit
- Reactivity: Human
- Sample Type: Serum, Plasma, Saliva, Body Fluids, Cell Culture Supernatant, Tissue Lysates
- Sensitivity: < 1.0 pg/ml
