- Created on the 7 February, 2017.
Leptin receptor (also called LEP-R, obese receptor and OB-R) is a single membrane-spanning receptor which belongs to the class I cytokine receptor family which includes: G-CSF receptor, LIF receptor and IL-6 receptor (gp130). LEP-R has a major role as a receptor that are specific for the fat cell hormone leptin, it is also designated as a cluster of differentiation 295 (CD295). It is primarily produced in adipose tissue and is able to bind leptin which is an approx. 16kDa double protein, this interaction of leptin with its receptor is intimately vital for regulating fat levels within the body. Another important role of leptin is to regulate blood pressure through the leptin receptor.
It is possible for the leptin receptor to have multiple splice forms, however, only the longest splice form is found to have any significant cytosolic domain and this appears sufficient for cytosolic signalling. This splice form has been shown to be over expressed in the hypothalamus and leads to the activation of STAT3 and STAT5. Since, leptin is able to control food intake and energy balance via the leptin receptor in the hypothalamus, this could suggest that many obesity or obesity-related diseases could be the result of some polymorphisms of the leptin receptor gene (LEPR).
Human leptin receptor ELISA kit is a reliable quantitative procedure for measuring leptin receptor (LEP-R) in human serum, plasma, cell culture supernatant, tissue lysates and body fluids. This assay has a minimum sensitivity detection limit of < 8.0 pg/ml.
The minimum sensitivity detection limit of leptin receptor (LEP-R) using this leptin receptor ELISA kit was approximately < 8.0 pg/ml. The dynamic assay range for this kit is 156.0 – 10,000.0 pg/ml.
- Hypertension in obesity and the leptin receptor gene locus. J. Clin. Endocr. Metab. (2000) 85: 3126-3131. Rosmond, R., et al.
- A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature (1998) 392: 398-401. Clement, K., et al.
- Identification and expression cloning of a leptin receptor, OB-R. Cell (1995) 83: 1263-1271. Tartaglia, L. A., et al.
- Polymorphisms in the leptin receptor (LEPR)–putative association with obesity and T2DM. J. Hum. Genet. (2006) 51: 85-91. Park, K. S., et al.
- Full Name: Leptin Receptor (LEP-R) ELISA Kit
- Reactivity: Human
- Sample Type: Serum, Plasma, Body Fluids, Cell Culture Supernatant, Tissue Lysates
- Sensitivity: < 8.0 pg/ml