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Lactoferrin Ab ELISA Kit

  • Created on the 12 June, 2017.

INTENDED USE

Human lactoferrin ELISA kit is intended for analysing in-vitro quantitative amounts of IgG auto-antibodies to lactoferrin Ab (LF, lactotransferrin, LTF, lactoferrin-IgG) in plasma or serum. This assay has a minimum analytical sensitivity limit of 0.5 U/ml.

BACKGROUND

Lactoferrin (LF) which can also be called lactotransferrin (LTF) is an iron binding protein which belongs to the transferrin family that is involved in the innate immune system. Apart from its main biological role of binding and transport of iron, it also possesses antiviral, anti-cancer, antibacterial, catalytic, anti-allergic and antiparasitic properties and functions. Lactoferrin mainly resides in specific granules of the polymorph nuclear neutrophil leukocytes (PMN) and can be present during secretions for example in tears, saliva or milk. Auto-antibodies against lactoferrin belong to the pANCA group and these are found to be at elevated levels in patients with ulcerative colitis, primary sclerosing cholangitis and rheumatoid vasculitis. During many active inflammatory disease, the higher serum concentrations of lactoferrin can be measured. The following lactoferrin ELISA kit is ideal for many different diagnostic applications.

SENSITIVITY

The minimum detection sensitivity level of human lactoferrin (lactotransferrin) IgG autoantibodies (lactoferrin-IgG) using current human lactoferrin ELISA kit was 0.5 U/ml. The dynamic range for this assay is 6.3 – 100.0 U/ml.

REFERENCES

  1. Immunomodulatory effects of lactoferrin. Acta Pharmacol Sin. (2014) 35 (5): 557-66. Review. Siqueiros-Cendón T., et al.
  2. Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine. Molecules. (2016) 21 (6). pii: E752. Review. Bruni N., et al.
  3. Lactoferrin: structure, function and applications. Int J Antimicrob Agents. (2009) 33 (4): 301.e1-8. Review. González-Chávez S.A., et al.
  4. LF immunomodulatory strategies: mastering bacterial endotoxin. Biochem Cell Biol. (2012) 90 (3): 269-78. Review. Latorre D., et al.
  5. Lactoferrin, a key molecule in immune and inflammatory processes. Biochem Cell Biol. (2012) 90 (3): 252-68. Review. Legrand D.
  6. Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties. Cell Mol Life Sci. (2005) 62 (22): 2588-98. Review. Gifford J.L., et al.

ADDITIONAL INFORMATION

  • Full Name: Lactoferrin Ab ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum, Plasma
  • Sensitivity: 0.5 U/ml

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