GET A QUOTE

Lactoferrin Ab ELISA Kit

  • Created on the 12 June, 2017.

BACKGROUND

Lactoferrin (LF) which can also be called lactotransferrin (LTF) is an iron binding protein which belongs to the transferrin family that is involved in the innate immune system. Apart from its main biological role of binding and transport of iron, it also possesses antiviral, anti-cancer, antibacterial, catalytic, anti-allergic and antiparasitic properties and functions. Lactoferrin mainly resides in specific granules of the polymorph nuclear neutrophil leukocytes (PMN) and can be present during secretions for example in tears, saliva or milk. Autoantibodies against lactoferrin belong to the pANCA group and these are found to be at elevated levels in patients with ulcerative colitis, primary sclerosing cholangitis and rheumatoid vasculitis. During many active inflammatory disease, the higher serum concentrations of lactoferrin can be measured.

INTENDED USE

Human lactoferrin ELISA kit is intended for analysing in-vitro quantitative amounts of IgG autoantibodies to lactoferrin (LF, lactotransferrin, LTF) in plasma or serum. This assay has a minimum analytical sensitivity limit of 0.5 U/ml.

SENSITIVITY

The minimum detection sensitivity level of human lactoferrin (lactotransferrin) IgG autoantibodies using this human lactoferrin ELISA kit was 0.5 U/ml. The dynamic assay range for this kit is 6.3 – 100.0 U/ml.

REFERENCES

  1. Immunomodulatory effects of lactoferrin. Acta Pharmacol Sin. (2014) 35 (5): 557-66. Review. Siqueiros-Cendón T., et al.
  2. Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine. Molecules. (2016) 21 (6). pii: E752. Review. Bruni N., et al.
  3. Lactoferrin: structure, function and applications. Int J Antimicrob Agents. (2009) 33 (4): 301.e1-8. Review. González-Chávez S.A., et al.
  4. LF immunomodulatory strategies: mastering bacterial endotoxin. Biochem Cell Biol. (2012) 90 (3): 269-78. Review. Latorre D., et al.
  5. Lactoferrin, a key molecule in immune and inflammatory processes. Biochem Cell Biol. (2012) 90 (3): 252-68. Review. Legrand D.
  6. Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties. Cell Mol Life Sci. (2005) 62 (22): 2588-98. Review. Gifford J.L., et al.

ADDITIONAL INFORMATION

  • Full Name: Lactoferrin Ab ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum, Plasma
  • Sensitivity: 0.5 U/ml

OTHER RELATED ELISA KITS

TESTIMONIALS arrow icon

Your secretory IgA ELISA kit gave good results and I was also really impressed with how quickly we received it.

L. Johnston
PhD Student / University of Glasgow

It is refreshing to know that you have a technical team that is very knowledgeable. I have already recommended your company to other researchers in our department.

Dr. P. Anderson
Lecturer / University College London (UCL)

I am a first time user and found that your instruction manual was very easy to follow. The insulin ELISA kit performed well and I was happy with the results that were generated.

J. Thomas
Senior Technician / Addenbrooke’s Hospital

I carried out a pilot study comparing the performance of many ELISA kits from different suppliers and found your kits to be one of the better performers. We observed good linearity and tight replicates.

Dr. C. Davies
Lead Scientists / AstraZeneca

You are my first point of contact when I am looking to purchase ELISA kits. You have such an easy and simple system, yet it is very effective.

A. Shaw
Purchasing / University of Oxford