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Kidney Injury Molecule 1 (KIM1) ELISA Kit

  • Created on the 28 March, 2017.

BACKGROUND

Kidney injury molecule 1 (KIM1) is also called hepatitis A virus cellular receptor 1, it is a transmembrane glycoprotein which is 339 amino acid in length where the N-terminal ectodomain contains the mucin and immunoglobulin-like domains. KIM-1 normally exists in very low levels in normal kidneys, however when upregulated during injury, it is detectable in urine in a number of different human diseases. It has been identified as a potential biomarker for renal injury, acute kidney failure or acute tubular necrosis and it has a great importance in many kidney disorders and diseases.

Several new early biomarkers of acute kidney injury (AKI) have indicated KIM-1 among the most promising ones. KIM-1 has not only been discovered as a sensitive diagnostic marker but also a predictive value for AKI in patients who are undergoing cardiac surgery. Accordingly, it has also been recently used as a nephrotoxicity biomarker during preclinical studies of drug candidates and the Food and Drug Administration (FDA) to identify KIM-1 as an appropriate biomarker for renal injury in preclinical studies of pharmacologic agents.

INTENDED USE

Human kim-1 ELISA kit can be used for detecting in vitro quantitative levels of kidney injury molecule 1 (KIM1) in human serum, plasma, urine, cell culture supernatant and cell lysates. This assay has a minimum detection limit of < 2.0 pg/ml.

SENSITIVITY

The minimum detection sensitivity level of kidney-injury molecule using this human kim-1 ELISA kit was 2.0 pg/ml. The dynamic assay range for this kit is 31.2 – 2,000 pg/ml.

REFERENCES

  1. Molecular markers of kidney injury. Urol Oncol. (2013) 31 (5): 682-5. Review. Lane B.R.
  2. Kidney injury molecule-1 in kidney disease. Ren Fail. (2016) 38 (10): 1567-1573. Yin C. and Wang N.
  3. Urinary and serum biomarkers for the diagnosis of acute kidney injury: an in-depth review of the literature. Nephrol Dial Transplant. (2013) 28 (2): 254-73. Review. Vanmassenhove J., et al.
  4. Kidney injury molecule-1: more than just an injury marker of tubular epithelial cells? J Cell Physiol. (2013) 228 (5): 917-24. Review. Lim A.I., et al.
  5. Emerging biomarkers and metabolomics for assessing toxic nephropathy and acute kidney injury (AKI) in neonatology. Biomed Res Int. (2014) 2014: 602526. Review. Mussap M., et al.

ADDITIONAL INFORMATION

  • Full Name: Kidney Injury Molecule 1 (KIM1) ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum,Urine, Cell Culture Supernatant, Plasma, Cell Lysates
  • Sensitivity: < 2.0 pg/ml

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