- Created on the 28 March, 2017.
Kidney injury molecule 1 (KIM1) is also called hepatitis A virus cellular receptor 1, it is a transmembrane glycoprotein which is 339 amino acid in length where the N-terminal ectodomain contains the mucin and immunoglobulin-like domains. KIM-1 normally exists in very low levels in normal kidneys, however when upregulated during injury, it is detectable in urine in a number of different human diseases. It has been identified as a potential biomarker for renal injury, acute kidney failure or acute tubular necrosis and it has a great importance in many kidney disorders and diseases.
Several new early biomarkers of acute kidney injury (AKI) have indicated KIM-1 among the most promising ones. KIM-1 has not only been discovered as a sensitive diagnostic marker but also a predictive value for AKI in patients who are undergoing cardiac surgery. Accordingly, it has also been recently used as a nephrotoxicity biomarker during preclinical studies of drug candidates and the Food and Drug Administration (FDA) to identify KIM-1 as an appropriate biomarker for renal injury in preclinical studies of pharmacologic agents.
Human kim-1 ELISA kit can be used for detecting in vitro quantitative levels of kidney injury molecule 1 (KIM1) in human serum, plasma, urine, cell culture supernatant and cell lysates. This assay has a minimum detection limit of < 2.0 pg/ml.
The minimum detection sensitivity level of kidney-injury molecule using this human kim-1 ELISA kit was 2.0 pg/ml. The dynamic assay range for this kit is 31.2 – 2,000 pg/ml.
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- Full Name: Kidney Injury Molecule 1 (KIM1) ELISA Kit
- Reactivity: Human
- Sample Type: Serum,Urine, Cell Culture Supernatant, Plasma, Cell Lysates
- Sensitivity: < 2.0 pg/ml