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Interleukin-9 (IL-9) ELISA Kit

  • Created on the 12 March, 2017.

BACKGROUND

Interleukin-9 (IL-9) is a pro-inflammatory cytokine which was originally identified as a 40KD glycoprotein with T-cell growth factor activity in mice. The human IL-9 was later discovered on the basis of its high level of homogeneity with the gene of mouse IL-9. Human IL-9 has be strongly associated with human malignant lymphoma and also demonstrated to be a stimulator for hematopoiesis. Furthermore, its expression has been found to be implicated with autoimmune and many allergic diseases.

Interleukin-9 is well studied as a therapeutic target for asthma due to it being implication with the disease.  IL-9 can be produced by Th2 cells which are under the stimulation of TGF-b and IL-4. This lineage has been shown to play vital role in the differentiation of Th17 cells and Treg function. There has been a renewed attention on IL-9 in recent years due to a unique type of innate lymphoid cells which have been discovered in mice where the main cell types expressing IL-9 secreting and in vivo cells present with the skin appear to mediate the inhibition of melanoma growth. These same interleukin-9 secreting cells have now also been identified in human and are being evaluated as a new tumour treatment strategy.

INTENDED USE

Interleukin-9 ELISA kit is designed for detecting in vitro quantitative concentrations of interleukin-9 (IL-9) present in human serum, plasma, cell culture supernatant and many other biological fluids. This assay has a minimum detection limit of < 0.343 pg/ml.

SENSITIVITY

The minimum detection sensitivity level of interleukin-9 (IL-9) using this human interleukin-9 ELISA kit was approximately 0.343 pg/ml. The dynamic assay range for this kit is 0.78 – 50 pg/ml.

REFERENCES

  1. Cellular sources and immune functions of interleukin-9. Nat Rev Immunol. (2010) 10 (10): 683-7. Review. Noelle R.J. and Nowak E.C.
  2.  A brief history of IL-9. J Immunol. (2011) 186 (6): 3283-8. Review. Goswami R. and Kaplan M.H.
  3. Th9 cells: differentiation and disease. Immunol Rev. (2013) 252 (1): 104-15. Review. Kaplan M.H.
  4. Interleukin-9 and mast cells. J Biol Regul Homeost Agents. (2012) 26 (3): 319-26. Review. Tete S., et al.
  5. Role of IL-9 in the pathophysiology of allergic diseases. J Allergy Clin Immunol. (2001) 107 (4): 575-82. Review. Soussi-Gounni A., et al.
  6. Interleukin 9 and its receptor: an overview of structure and function. Int Rev Immunol. (1998) 16 (3-4): 345-64. Review. Demoulin J.B. and Renauld J.C.

ADDITIONAL INFORMATION

  • Full Name: Interleukin-9 (IL-9) ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum, Plasma, Cell Culture Supernatant, Other Biological Fluids
  • Sensitivity: < 0.343 pg/ml

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