Interleukin-22 ELISA kit is designed for measuring in vitro quantitative amounts of interleukin-22 (IL-22) in human serum, plasma, cell culture supernatant and other biological fluids. This assay has a minimum detection limit of < 9.2 pg/ml.
Interleukin-22 (IL-22) which is also called TIF (IL-10-related T cell-derived inducible factor), a newly identified cytokine which displays 22% amino acid homology to IL-10 and signals through class II cytokine receptor proteins. IL-22 can be produced by dendritic cells, natural killer cells and T-cells during either a tissue inflammation, bacterial infection or auto-immunity. It has the ability to act upon innate immunity cells via its receptors which are known to be expressed exclusively on these cells. This gives it an important function as a protective molecule which has the ability to counteract the destructive nature of the immune response in order to limit the damage to these tissues.
The following interleukin-22 ELISA kit can be used for analysing a variety of diagnostic applications. Recently, an IL-22 expressing T helper cell subset which is referred to as Th22 has been characterized. It is distinct from the other T cells due to the fact it can be co-expressed with the skin-homing receptors CCR4 or CCR10 and the chemokine receptor CCR6. The expression of IL-22 is found to be also elevated in psoriatic skin inflammation, inflammatory bowel disease and atopic dermatitis. Psoriatic patients display a strong elevation of IL-22 plasma levels, which also directly correlates with the disease severity. The expression of IL-22 in CD4+ T helper cells has been found to be linked with Th7 and Th17. This interleukin-22 ELISA kit offers a sensitivity level of 9.2 pg/ml and it can be used to measure human samples of cell culture supernatant, plasma, biological fluids and serum.
The minimum detection sensitivity level of IL-22 (interleukin-22) using current human interleukin-22 ELISA kit was approximately 9.2 pg/ml. The dynamic range for this assay is 18.8 – 600 pg/ml.
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- Full Name: Interleukin-22 (IL-22) ELISA Kit
- Reactivity: Human
- Sample Type: Plasma, Cell Culture Supernatant, Serum, Other Biological Fluids
- Sensitivity: < 9.2 pg/ml