- Created on the 16 March, 2017.
Interleukin-22 (IL-22) which is also called TIF (IL-10-related T cell-derived inducible factor), a newly identified cytokine which displays 22% amino acid homology to IL-10 and signals through class II cytokine receptor proteins. IL-22 can be produced by dendritic cells, natural killer cells and T-cells during either a tissue inflammation, bacterial infection or auto-immunity. It has the ability to act upon innate immunity cells via its receptors which are known to be expressed exclusively on these cells. This gives it an important function as a protective molecule which has the ability to counteract the destructive nature of the immune response in order to limit the damage to these tissues.
Recently, an IL-22 expressing T helper cell subset which is referred to as Th22 has been characterized. It is distinct from the other T cells due to the fact it can be co-expressed with the skin-homing receptors CCR4 or CCR10 and the chemokine receptor CCR6. The expression of IL-22 is found to be also elevated in psoriatic skin inflammation, inflammatory bowel disease and atopic dermatitis. Psoriatic patients display a strong elevation of IL-22 plasma levels, which also directly correlates with the disease severity. The expression of IL-22 in CD4+ T helper cells has been found to be linked with Th7 and Th17.
Interleukin-22 ELISA kit is designed for measuring in vitro quantitative amounts of interleukin-22 (IL-22) in human serum, plasma, cell culture supernatant and other biological fluids. This assay has a minimum detection limit of < 9.2 pg/ml.
The minimum detection sensitivity level of interleukin-22 (IL-22) using this human interleukin-22 ELISA kit was approximately 9.2 pg/ml. The dynamic assay range for this kit is 18.8 – 600 pg/ml.
- Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair? Nat Rev Immunol. (2009) 9 (4): 229-34. Review. Vivier E., et al.
- Role of interleukin-22 in inflammatory bowel disease. World J Gastroenterol. (2014) 20 (48): 18177-88. Review. Li L.J., et al.
- Role of IL-17 and IL-22 in autoimmunity and cancer. Actas Dermosifiliogr. (2014) 105 Suppl 1: 41-50. Review. Blake S.J. and Teng M.W.
- Biological and pathological activities of interleukin-22. J Mol Med (Berl). (2016) 94 (5): 523-34. Review. Perusina Lanfranca M., et al.
- Distinct roles of IL-22 in human psoriasis and inflammatory bowel disease. Cytokine Growth Factor Rev. (2010) 21 (6): 435-41. Review. Ouyang W.
- Full Name: Interleukin-22 (IL-22) ELISA Kit
- Reactivity: Human
- Sample Type: Plasma, Cell Culture Supernatant, Serum, Other Biological Fluids
- Sensitivity: < 9.2 pg/ml