GET A QUOTE

Interleukin-22 (IL-22) ELISA Kit

  • Created on the 16 March, 2017.

BACKGROUND

Interleukin-22 (IL-22) which is also called TIF (IL-10-related T cell-derived inducible factor), a newly identified cytokine which displays 22% amino acid homology to IL-10 and signals through class II cytokine receptor proteins. IL-22 can be produced by dendritic cells, natural killer cells and T-cells during either a tissue inflammation, bacterial infection or auto-immunity. It has the ability to act upon innate immunity cells via its receptors which are known to be expressed exclusively on these cells. This gives it an important function as a protective molecule which has the ability to counteract the destructive nature of the immune response in order to limit the damage to these tissues.

Recently, an IL-22 expressing T helper cell subset which is referred to as Th22 has been characterized. It is distinct from the other T cells due to the fact it can be co-expressed with the skin-homing receptors CCR4 or CCR10 and the chemokine receptor CCR6. The expression of IL-22 is found to be also elevated in psoriatic skin inflammation, inflammatory bowel disease and atopic dermatitis. Psoriatic patients display a strong elevation of IL-22 plasma levels, which also directly correlates with the disease severity. The expression of IL-22 in CD4+ T helper cells has been found to be linked with Th7 and Th17.

INTENDED USE

Interleukin-22 ELISA kit is designed for measuring in vitro quantitative amounts of interleukin-22 (IL-22) in human serum, plasma, cell culture supernatant and other biological fluids. This assay has a minimum detection limit of < 9.2 pg/ml.

SENSITIVITY

The minimum detection sensitivity level of interleukin-22 (IL-22) using this human interleukin-22 ELISA kit was approximately 9.2 pg/ml. The dynamic assay range for this kit is 18.8 – 600 pg/ml.

REFERENCES

  1. Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair? Nat Rev Immunol. (2009) 9 (4): 229-34. Review. Vivier E., et al.
  2. Role of interleukin-22 in inflammatory bowel disease. World J Gastroenterol. (2014) 20 (48): 18177-88. Review. Li L.J., et al.
  3. Role of IL-17 and IL-22 in autoimmunity and cancer. Actas Dermosifiliogr. (2014) 105 Suppl 1: 41-50. Review. Blake S.J. and Teng M.W.
  4. Biological and pathological activities of interleukin-22. J Mol Med (Berl). (2016) 94 (5): 523-34. Review. Perusina Lanfranca M., et al.
  5. Distinct roles of IL-22 in human psoriasis and inflammatory bowel disease. Cytokine Growth Factor Rev. (2010) 21 (6): 435-41. Review. Ouyang W.

ADDITIONAL INFORMATION

  • Full Name: Interleukin-22 (IL-22) ELISA Kit
  • Reactivity: Human
  • Sample Type: Plasma, Cell Culture Supernatant, Serum, Other Biological Fluids
  • Sensitivity: < 9.2 pg/ml

OTHER RELATED ELISA KITS

TESTIMONIALS arrow icon

Your secretory IgA ELISA kit gave good results and I was also really impressed with how quickly we received it.

L. Johnston
PhD Student / University of Glasgow

It is refreshing to know that you have a technical team that is very knowledgeable. I have already recommended your company to other researchers in our department.

Dr. P. Anderson
Lecturer / University College London (UCL)

I am a first time user and found that your instruction manual was very easy to follow. The insulin ELISA kit performed well and I was happy with the results that were generated.

J. Thomas
Senior Technician / Addenbrooke’s Hospital

I carried out a pilot study comparing the performance of many ELISA kits from different suppliers and found your kits to be one of the better performers. We observed good linearity and tight replicates.

Dr. C. Davies
Lead Scientists / AstraZeneca

You are my first point of contact when I am looking to purchase ELISA kits. You have such an easy and simple system, yet it is very effective.

A. Shaw
Purchasing / University of Oxford