Human ICAM-1 ELISA kit can be used for measuring in vitro quantitative amounts of intercellular adhesion molecule-1 (ICAM1, CD54, ICAM-1) in human plasma, cell culture supernatant, cell lysates, serum and many other biological fluids. This assay has a minimum sensitivity limit of 9.98 ng/L.
Intercellular adhesion molecule-1 (ICAM-1, ICAM1) is also called CD54 and is essentially a cell surface glycoprotein that is mostly expressed on immune system and endothelial cells. ICAM-1 is a transmembrane protein which contains a single transmembrane domain, a carboxy-terminus cytoplasmic domain and an amino-terminus extracellular domain. The extracellular domain possesses many loops which are due to disulphide bridges present. ICAM-1 is important in facilitating leukocyte endothelial transmigration and in stabilising cell-cell interactions. It is a ligand for LFA-1 (integrin), a vital receptor present on leukocytes and it can also interact with CD18, CD11a and EZR.
The following ICAM-1 ELISA kit is designed to be used for analysing a variety of diagnostic applications. Intercellular adhesion molecule-1 is found on fibroblasts, leukocytes, endothelial and epithelial cells, its expression is mainly regulated by inflammatory cytokines. It possesses a tissue distribution which is very similar to that of many other major histocompatibility complex class II antigens and this is likely to be crucial in a number of inflammatory responses. The dominant secondary structure for this protein is of a beta sheet with the possibility of dimerization domains being also present within the ICAM-1 molecules. This CAM-1 ELISA kit offers a detection sensitivity limit of 9.98 ng/L and can be used to measure human samples of cell lysates, plasma, serum, biological fluids and cell culture supernatant.
The minimum detection sensitivity level of intercellular adhesion molecule-1 (ICAM-1, CD54, ICAM1) using current human ICAM-1 ELISA kit was 9.98 ng/L. The dynamic range for this assay is 20.0 – 6,000 ng/L.
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- Full Name: Intercellular Adhesion Molecule-1 (ICAM-1) ELISA Kit
- Reactivity: Human
- Sample Type: Serum, Cell Lysates, Other Biological Fluids, Cell Culture Supernatant, Plasma
- Sensitivity: 9.98 ng/L