GET A QUOTE

Insulin-like Growth Factor Binding Protein-2 (IGFBP-2) ELISA Kit

  • Created on the 6 February, 2017.

BACKGROUND

Insulin-like growth factor binding protein-2 (IGFBP-2) is an unglycosylated 31.3kDa polypetide protein which shows no circadian rhythm in circulation and forms binary IGF-complexes. The IGFBP-2 concentration in blood is age-dependent and the serum concentration is found to increase during fasting state, after trauma, after any major surgery and in malignant diseases. It is most intensive in malignant diseases where the correlation of the IGFBP-2 level to the degree of progression can be a striking feature in a number of different tumour types as is the normalisation of the IGFBP serum levels after remission. During the GH-therapy, for example in GH abuse (doping) and in short stature the IGFBP-2 levels have been found to decrease. Also, in trisomy 18 IGFBP-2 in maternal serum is decreased and IGFBP-1 is increased, this allows the ratio IGFBP-2 /IGFBP-1 to be a good indicator/marker for chromosome abnormality. Normal values for healthy individuals (ranging in age from 1.5 to > 70 years) have been evaluated using this ELISA assay.

INTENDED USE

Human IGFBP-2 ELISA kit is a reliable quantitative procedure for measuring insulin-like growth factor binding protein-2 (IGFBP-2) in human serum, plasma, CSF, saliva and other body fluids. This assay has a minimum sensitivity detection limit of 0.02 ng/ml.

SENSITIVITY

The minimum sensitivity detection limit of insulin-like growth factor binding protein-2 (IGFBP-2) using this IGFBP-2 ELISA kit was approximately 0.02 ng/ml. The dynamic assay range for this kit is 2.0 – 80.0 ng/ml.

REFERENCES

  1. IGFBP-2: The dark horse in metabolism and cancer. Cytokine Growth Factor Rev. (2015) 26 (3): 329-46. Review. Russo V.C., et al.
  2. Protein molecular forms of insulin-like growth factor binding protein-2 change with aging. Exp Gerontol. (2014) 58: 154-8. Sunderić M., Mihailović N. and Nedić O.
  3. Insulin-like growth factor binding protein-2 as a novel biomarker for disease activity and renal pathology changes in lupus nephritis. Clin Exp Immunol. (2016) 184 (1): 11-8. Ding H., et al.
  4. IGFBP-2 directly stimulates osteoblast differentiation. J Bone Miner Res. (2014) 29 (11): 2427-38. Xi G., et al.

ADDITIONAL INFORMATION

  • Full Name: Insulin-like Growth Factor Binding Protein-2 (IGFBP-2) ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum, Plasma, Saliva, CSF, Other Body Fluids
  • Sensitivity: 0.02 ng/ml

OTHER RELATED ELISA KITS

TESTIMONIALS arrow icon

Your secretory IgA ELISA kit gave good results and I was also really impressed with how quickly we received it.

L. Johnston
PhD Student / University of Glasgow

It is refreshing to know that you have a technical team that is very knowledgeable. I have already recommended your company to other researchers in our department.

Dr. P. Anderson
Lecturer / University College London (UCL)

I am a first time user and found that your instruction manual was very easy to follow. The insulin ELISA kit performed well and I was happy with the results that were generated.

J. Thomas
Senior Technician / Addenbrooke’s Hospital

I carried out a pilot study comparing the performance of many ELISA kits from different suppliers and found your kits to be one of the better performers. We observed good linearity and tight replicates.

Dr. C. Davies
Lead Scientists / AstraZeneca

You are my first point of contact when I am looking to purchase ELISA kits. You have such an easy and simple system, yet it is very effective.

A. Shaw
Purchasing / University of Oxford