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Inhibin B II, Gen ELISA Kit

  • Created on the 20 February, 2017.

BACKGROUND

Inhibin B consists of a dimer of 2 homologous subunits, an alpha subunit and beta B subunit. These are found to be secreted in males by sertoli cells of the testes and in females by granulosa cells of the ovary. In males, the levels of inhibin B is found to be much greater in men with apparently normal fertility when compared to those with abnormal spermatogenesis and infertility. This has caused many researcher to believe that serum inhibin B when used alongside FSH can provide greater sensitivity marker for spermatogenesis than FSH used alone.

Another function of inhibin B is to provide a useful marker for ovarian reserve, the most common tests that are used to assess ovarian reserve include: FSH (day 3), inhibin B (day 3) and anti-mullerian hormone levels. The concentrations of inhibin B determined in serum in the early follicular phase of the menstrual cycle (usually at day 3) is a good reflection of the number of follicles in the ovary. The amount of inhibin B measured in serum directly reflects the number of follicles in the ovary (i.e. the higher the levels of inhibin B the greater the number of ovarian follicles present).

Inhibin B is found to be a suitable serum marker for epithelial tumors of the mucinous type where between 55-60% patients tested displayed elevated levels of inhibin B. Also over 90% patients with granulosa cell tumors were found with elevated inhibin B concentrations, this represented a value which was around 60-fold greater that the reference range value.

INTENDED USE

Inhibin B ELISA kit is a reliable quantitative procedure for measuring inhibin B II, Gen in human serum and lithium heparin plasma. This assay has a minimum sensitivity detection limit of 2.6 pg/ml.

SENSITIVITY

The minimum sensitivity detection limit of inhibin B Gen II using this human inhibin B ELISA kit was approximately 2.6 pg/ml. The dynamic assay range for this kit is 11.0 – 977.0 pg/ml.

REFERENCES

  1. Inhibin B in male reproduction: pathophysiology and clinical relevance. Eur J Endocrinol. (2001) 145 (5): 561-71. Review. Meachem S.J., et al.
  2. Regulation of inhibin production in the human male and its clinical applications. Int J Androl. (2000) 23 (3): 136-44. Review. Anderson R.A. and Sharpe R.M.
  3. Solely inhibin B producing ovarian tumour as a cause of secondary amenorrhoea with hot flushes: case report and review of literature. Hum Reprod. (2012) 27 (4): 1144-8. van Liempt S.W., et al.
  4. Inhibins and adult ovarian function. Mol Cell Endocrinol. (2004) 225 (1-2): 37-44. Review. Laven J.S. and Fauser B.C.

ADDITIONAL INFORMATION

  • Full Name: Inhibin B II, Gen ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum, Lithium Heparin Plasma
  • Sensitivity: 2.6 pg/ml

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