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Fungal Diseases

Diagnosis of fungal disease traditionally relies on methods such as culture, histopathology and direct microscopic examination of clinical samples. Such approaches require relatively high levels of specific mycology training and they lack specificity, sensitivity and take a long time to yield a result which can be clinical useful. This has led to an increased emphasis on the development of molecular methods and antigen detection systems. Fungal polysaccharides and proteins are usually shed into body fluids during the course of an infection. This can lead to the possibility of developing specific antibodies against such shed antigens, an immunoassay can be constructed which is more specific, sensitive and reliable.

There are many advantages of using ELISA kits for testing fungal diseases when compared to the conventional methods.

  • Immunoassay methods can be more reliable, specific, sensitive and yield clinical relevant results quickly.
  • Highly invasive sample collection methods may not be required because the antigen is shed to body fluids such as blood or urine.
  • Possibility of producing an immunoassay with a broad or a very limited specificity based on the properties of the antibody that is selected and on the clinical requirements for testing.
  • Limited training is required in comparison to the high levels of specific mycology training when using traditional methods.

It is likely that several diagnostic methods will be required in order to meet the diverse needs of different fungal infections. Early diagnosis is important because it will allow the administration of anti-fungal during the time when it is most likely to be effective. Unlike most bacterial or viral infection, fungal diseases typically develop gradually and clear slowly.

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Your secretory IgA ELISA kit gave good results and I was also really impressed with how quickly we received it.

L. Johnston
PhD Student / University of Glasgow

It is refreshing to know that you have a technical team that is very knowledgeable. I have already recommended your company to other researchers in our department.

Dr. P. Anderson
Lecturer / University College London (UCL)

I am a first time user and found that your instruction manual was very easy to follow. The insulin ELISA kit performed well and I was happy with the results that were generated.

J. Thomas
Senior Technician / Addenbrooke’s Hospital

I carried out a pilot study comparing the performance of many ELISA kits from different suppliers and found your kits to be one of the better performers. We observed good linearity and tight replicates.

Dr. C. Davies
Lead Scientists / AstraZeneca

You are my first point of contact when I am looking to purchase ELISA kits. You have such an easy and simple system, yet it is very effective.

A. Shaw
Purchasing / University of Oxford