- Created on the 28 March, 2018.
Rat/Mouse IGF-1 ELISA kit can be used for measuring quantitative levels of mouse or rat insulin-like growth factor-1 (IGF1, IGF-1) using serum and plasma samples. This assay has a minimum sensitivity detection limit of < 0.029 ng/ml.
Insulin-like growth factor 1 (IGF-1) is also referred to as somatomedin C, it is a sulfaction factor which has a similar molecular structure as insulin and it also possesses non-suppressible insulin-like activity. IGF-1 has a molecular weight of 7,649 Da, containing a single chain of 70 amino acids that is held together by three intracellular disulphide bridges. It is mainly produced as an endocrine hormone through the liver and has the ability to target specific tissues in either an autocrine or a paracrine manner. IGF-1 is the predominate mediator of growth hormone effects, which are found to be mediated via IGF1R receptor, leading to the activation of the AKT signalling pathway. This can result in the stimulation of cell growth and proliferation, it is a potent inhibitor of programmed cell death.
The standard range of rat or mouse insulin-like growth factor-1 (IGF1) using current rat/mouse IGF-1 ELISA kit was approximately 0.029 ng/ml. The dynamic range for this assay is 0.5 – 18.0 ng/ml.
- Aging, atherosclerosis, and IGF-1. J Gerontol A Biol Sci Med Sci. (2012) 67 (6): 626-39. Review. Higashi Y., et al
- Serum IGF-1 levels correlate negatively to liver damage in diabetic rats. Biotech Histochem. (2013) 88 (3-4): 194-201. Aksu I., et al
- The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances. J Gerontol A Biol Sci Med Sci. (2012) 67 (6): 599-610. Review. Ungvari Z. and Csiszar A.
- Regulation of IGF-1/PI3K/Akt signalling by the phosphoinositide phosphatase pharbin. J Biochem. (2011) 150 (1): 83-93. Wang F., et al.
- Full Name: IGF-1 ELISA Kit (Rat/Mouse)
- Reactivity: Mouse, Rat
- Sample Type: Serum, Plasma
- Sensitivity: < 0.029 ng/ml