- Created on the 12 June, 2017.
Histones autoantibodies are highly conserved in many species and are the major basic protein that is found in chromatin. There are essentially 5 different classes of histone (H1, H2, H2b, H3 and H4), ranging in molecular weight from 11-23 kD and all containing the arginine and lysine basic amino acids. Histone autoantibodies are a type of antinuclear antibodies (ANA) which are known to be associated to many different autoimmune diseases such as lupus. The presence or even an absence of a particular antinuclear antibodies can be a useful aid in determining a specific disorder. There is evidence that drugs can be used to stimulate the production of histone antibodies but there is also a possibility that this can lead to a type of lupus (drug-induced lupus erythematosus). Many drugs have been associated with drug-induced lupus in some people such as hydralazine, penicillamine, isoniazid, quinidine, procainamide and minocycline. However, majority of anti-histone antibodies in drug induced lupus erythematosus are of temporary character and tend to disappear within a few months after treatment.
Human histone ELISA kit is a method for measuring in-vitro quantitative amounts of IgG autoantibodies to histone in human serum or plasma. This assay has a minimum analytical sensitivity limit of 1.0 U/ml.
The minimum detection sensitivity level of human histone IgG autoantibodies using this human histone ELISA kit was 1.0 U/ml. The dynamic assay range for this kit is 12.5 – 200.0 U/ml.
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- Full Name: Histone Ab ELISA Kit
- Reactivity: Human
- Sample Type: Serum, Plasma
- Sensitivity: 1.0 U/ml