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High Sensitive Cardiac Troponin (hs-cTn) ELISA Kit

  • Created on the 16 May, 2017.

BACKGROUND

Cardiac troponins have now become the markers of choice for patients with acute coronary syndrome (ACS). The troponins are regulatory proteins which are present in cardiac and skeletal muscles. Currently, there are three different subunits that have been identified: troponin C (TnC), troponin T (TnT) and troponin I (TnI). The skeletal and cardiac subforms for TnI and troponin TnT are distinct and this has led to the development of many immunoassays in order to differentiate between them. Whereas, the cardiac and skeletal isoforms of TnC are identical and display no structural difference between them. Rapid advances in immunoassay technologies has allowed manufacturers to develop and produce troponin assays with unprecedented precision and high analytic sensitivity. These assays can now detect plasma cTn levels as low as 0.006 ng/mL and over a range that is between 0.006–50 ng/mL. It is now even possible to measure low levels of cTn in the plasma samples of healthy individuals.

INTENDED USE

Human hs-cardiac troponin ELISA kit is intended for measuring in vitro quantitative concentrations of high sensitive cardiac troponin (hs-cTn) in human plasma, cell lysates, serum, other biological fluids and cell culture supernatant. This assay has a minimum sensitivity limit of 0.005 ng/ml.

SENSITIVITY

The minimum detection sensitivity level of human hs-cTn using this human hs-cardiac troponin ELISA kit was 0.005 ng/ml. The dynamic assay range for this kit is 0.1 – 40.0 ng/ml.

REFERENCES

  1. Highly sensitive cardiac troponin assays: a comprehensive review of their clinical utility. Cardiol Rev. (2015) 23 (6): 282-9. Review. Segraves J.M. and Frishman W.H.
  2. High-sensitivity cardiac troponins in everyday clinical practice. World J Cardiol. (2014) 6 (4): 175-82. Review. Mair J.
  3. Present and Future of Cardiac Troponin in Clinical Practice: A Paradigm Shift to High-Sensitivity Assays. Am J Med. (2016) 129 (4): 354-65. Review. Sandoval Y., et al.
  4. Will high-sensitivity troponin assays lead to improved outcomes in patients with acute coronary syndrome? Coron Artery Dis. (2013) 24 (8): 713-5. Review. McCord J.

ADDITIONAL INFORMATION

  • Full Name: High Sensitive Cardiac Troponin (hs-cTn) ELISA Kit
  • Reactivity: Human
  • Sample Type: Cell Lysates, Serum, Plasma, Cell Culture Supernatant, Other Biological Fluids
  • Sensitivity: 0.005 ng/ml

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