- Created on the 22 March, 2017.
Human hs-CRP ELISA kit is a method for analysing in vitro quantitative concentrations of high sensitive c-reactive protein (hs-CRP) in human serum and plasma. This assay has a minimum detection limit of < 0.02 µg/ml.
C-reactive protein (CRP) is produced exclusively in the liver and it is interleukin-6 (IL-6) which is the chief mediator for the synthesis of CRP by hepatocytes. It has a total approx. molecular mass of 120.000 Daltons and is made up of a symmetrical pentamer structure. Human CRP is essentially a kind of non-immunoglobulin serum substance which is also a heat labile beta-globulin. It is found to be present in the active stages of many inflammatory disorders such as rheumatoid arthritis, psoriatric arthropathy, Crohn’s disease, systemic lupus erythematosus, Reiter’s syndrome, polyarteritis, ankylosing spondylitis and ulcerative colitis.
The CRP-level can increases dramatically after microbial infections and this property has been particularly helpful for the diagnosis and monitoring a large number of bacterial septicemia in neonates and in many other immune-compromised patients. The concentrations of CRP begin to rise within 6 hours of an acute inflammatory challenge. Also, many injuries that are responsible for causing necrosis and tissue breakdown are also found to elevate serum CRP levels, examples of these are observed in major surgery, myocardial infarction and thermal burns. A number of widespread malignant diseases including Hodgkin’s disease, lymphosarcoma, non-Hodgkin’s lymphoma and many carcinomas (lung, pancreas, stomach, breast, colon and prostate) can also give rise to high levels of CRP which result from tissue damage that is caused by invading tumour cells. Therefore, the following hs-CRP ELISA kit can be used as a viable marker to monitor malignancy.
The minimum detection sensitivity level of c-reactive protein (CRP) using current human hs-CRP ELISA kit was 0.02 µg/ml. The dynamic range for this assay is 0.4 – 10.0 µg /ml.
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- Full Name: High Sensitive C-Reactive Protein (hs-CRP) ELISA Kit
- Reactivity: Human
- Sample Type: Plasma, Serum
- Sensitivity: < 0.02 µg/ml