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Herpes Simplex 1/2 IgG ELISA Kit

  • Created on the 22 August, 2017.

BACKGROUND

Herpes simplex virus (HSV) types 1 and 2 belong to the Herpesviridae family and are found to produce infection which can differ from mild stomatitis to disseminated and fatal disease. The infections caused by HSV 1 and 2 are known to differ greatly in their severity and clinical manifestations. Some of the clinical conditions that have been linked with HSV infection include disseminated primary infection, vesicular skin eruptions, keratitis, gingivostomatitis, aseptic meningitis, encephalitis, genital tract infections and neonatal herpes. HSV 1 is usually closely linked with orolabial infection but there is also evidence of genital infection among certain populations. Whereas, HSV 2 has been found to cause primarily urogenital infections and is usually exclusively only occurring in adults. The diagnosis HSV infections is routinely made based on clinical findings and supported by laboratory testing using PCR or viral culture. For typing of HSV 1/HSV 2 indirect immunofluorescence or Western blots can be performed. The diagnosis of the primary infection by HSV 1/HSV 2 can be identified by a significant elevation of IgG within 6 to 10 days following infection, a finished infection is usually monitored by the IgG ELISA assay.

INTENDED USE

Human HSV-1/2 IgG ELISA kit is intended for in-vitro quantitative detection of human IgG antibodies to herpes simplex virus 1/2 (HSV-1/2) in plasma or serum. This assay has a minimum analytical sensitivity limit of 1.2 U/ml.

SENSITIVITY

The minimum detection sensitivity level of human herpes simplex virus-1/2 (HSV-1/2) IgG using this human HSV-1/2 IgG ELISA kit was 1.2 U/ml. The dynamic assay range for this kit is 1.0 – 200.0 U/ml.

REFERENCES

  1. Herpes Simplex Virus: Beyond the Basics. Neonatal Netw. (2015) 34 (5): 279-83. Review. Kobty M.
  2. Prospects for a vaccine against herpes simplex virustypes 1and 2. Prog Med Virol. (1987) 34: 89-128. Review. Dix R.D.
  3. Prospects and perspectives for development of a vaccine against herpes simplex virus infections. Expert Rev Vaccines. (2014) 13 (11): 1349-60. Review. McAllister S.C. and Schleiss M.R.
  4. Herpes simplex virustype 2 and HIV disease progression: a systematic review of observational studies. BMC Infect Dis. (2013) 13: 502. Review. Tan D.H., et al.

ADDITIONAL INFORMATION

  • Full Name: Herpes Simplex Virus 1/2 IgG ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum, Plasma
  • Sensitivity: 1.2 U/ml

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