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Helicobacter Pylori IgA ELISA Kit

  • Created on the 23 August, 2017.

BACKGROUND

Helicobacter pylori which is most often shortened to H. pylori is a gram negative microaerophilic bacterium that can be found living in the sticky mucus that lines the stomach. They are spiral/helix-shaped bacteria that are often classified as curved rod, about 0.5μm in diameter and 3μm in length. H. pylori bacteria are unique by the fact they produce the enzyme urease themselves which allows it to live in the harsh environment of the stomach. The infections caused by H. pylori are mostly harmless, however, they can be responsible for a large number of ulcers that are found in the stomach or the small intestines. H. pylori is considered contagious and can be passed from person to person by saliva, fecal contamination and through poor hygiene practices. Helicobacter pylori can be detected serologically by carrying out ELISA assay or by Western Blot. Through the analysis of immunoglobulins using ELISA method, the detection of IgG, IgA and IgM antibodies to specific Helicobacter pylori protein in Western Blots, it makes it possible to diagnose acute infections or even no germs can be found with H. pylori.

INTENDED USE

Human helicobacter pylori-IgA ELISA kit is a procedure for in-vitro quantitative analysis of human IgA antibodies to helicobacter pylori using plasma or serum. This assay has a minimum analytical sensitivity limit of 1.0 U/ml.

SENSITIVITY

The minimum detection sensitivity level of human helicobacter pylori IgA using this human helicobacter pylori-IgA ELISA kit was 1.0 U/ml. The dynamic assay range for this kit is 1.0 – 200.0 U/ml.

REFERENCES

  1. Helicobacter pylori participates in the pathogenesis of IgA nephropathy. Ren Fail. (2016) 38 (9): 1398-1404. Zhu T.T., et al.
  2. Decreased Helicobacter pylori-specific gastric secretory IgA antibodies in infected patients. Digestion. (1998) 59 (6): 638-45. Birkholz S., et al.
  3. Relationship between mucosal levels of Helicobacter pylori-specific IgA, interleukin-8 and gastric inflammation. Clin Sci (Lond). (1999) 96 (4): 409-14. Zhang Q.B., et al.
  4. Investigation of human colostrum Helicobacter pylori IgA content in lactating women. Eur J Obstet Gynecol Reprod Biol. (2006) 124 (1): 58-60. Tanriverdi H.A., et al.
  5. Helicobacter pylori infections in IgA deficiency: lack of role for the secretory immune system. Clin Exp Immunol. (1996) 105 (2): 202-4. Bogstedt A.K., et al.

ADDITIONAL INFORMATION

  • Full Name: Helicobacter Pylori IgA ELISA Kit
  • Reactivity: Human
  • Sample Type: Plasma, Serum
  • Sensitivity: 1.0 U/ml

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