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GIP Active Form ELISA Kit (Rat)

  • Created on the 22 February, 2018.

BACKGROUND

Gastric inhibitory polypeptide (GIP) is a proprotein which is made up of 153 amino acids, it is a member of the secretin family. One of the primary function of this protein is to stimulate the secretion of insulin, other important roles include inhibiting the secretion of gastric acid and thereby aiding in protecting the small intestines from getting damaged by the stomach acid. There are recent finding indicating that GIP could have critical roles in bone remodelling and the absence of GIP receptors have a direct correlation to resistance to obesity in knockout mice experiments.

INTENDED USE

Rat GIP active ELISA kit is designed for quantitative analysis of rat gastric inhibitory polypeptide (GIP) active form using plasma-EDTA. This assay has a minimum sensitivity detection limit of 0.43 pg/ml.

SENSITIVITY

The minimum sensitivity detection limit of rat active form gastric inhibitory polypeptide (GIP) using this rat GIP active ELISA kit was approximately 0.43 pg/ml. The dynamic assay range for this kit is 2.3 – 150.0 pg/ml.

REFERENCES

  1. Release of gastric inhibitory polypeptide (GIP) by intraduodenal acidification in rats and humans and abolishment of the incretin effect of acid by GIP-antiserum in rats. Gastroenterology. (1979) 76 (3): 515-23. Ebert R., et al.
  2. Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans. Am J Physiol Gastrointest Liver Physiol. (2014) 306 (7): G622-30. Kuhre R.E., et al.
  3. Gastric inhibitory polypeptide (GIP) binding sites in rat brain. Peptides. (1994) 15 (2): 297-302. Kaplan A.M. and Vigna S.R.
  4. Dietary 1-monoolein decreases postprandial GIP release by reducing jejunal transport of glucose and fatty acid in rodents. Am J Physiol Gastrointest Liver Physiol. (2012) 303 (3): G298-310. Shimotoyodome A., et al.

ADDITIONAL INFORMATION

  • Full Name: GIP Active Form ELISA Kit (Rat)
  • Reactivity: Rat
  • Sample Type: EDTA-Plasma
  • Sensitivity: 0.43 pg/ml

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