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GIP Active Form ELISA Kit (Rat)

  • Created on the 22 February, 2018.

BACKGROUND

Gastric inhibitory polypeptide (GIP) is a member of the secretin family of hormones and one of its major functions is stimulating the secretion of insulin. It can also help in the protection of the small intestine from stomach acid by acting as a weak inhibitor of gastric acid. It can be synthesised by K cells and circulates as a biologically active peptide of 42 amino acids in length. It is transported by blood similar to all other endocrine hormones. GIP has also been associated with important roles in bone remodelling, obesity and Type 2 diabetes.

INTENDED USE

Rat GIP active ELISA kit is designed for quantitative analysis of rat gastric inhibitory polypeptide (GIP) active form using plasma-EDTA. This assay has a minimum sensitivity detection limit of 0.43 pg/ml.

SENSITIVITY

The minimum sensitivity detection limit of rat active form gastric inhibitory polypeptide (GIP) using this rat GIP active ELISA kit was approximately 0.43 pg/ml. The dynamic assay range for this kit is 2.3 – 150.0 pg/ml.

REFERENCES

  1. Release of gastric inhibitory polypeptide (GIP) by intraduodenal acidification in rats and humans and abolishment of the incretin effect of acid by GIP-antiserum in rats. Gastroenterology. (1979) 76 (3): 515-23. Ebert R., et al.
  2. Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans. Am J Physiol Gastrointest Liver Physiol. (2014) 306 (7): G622-30. Kuhre R.E., et al.
  3. Gastric inhibitory polypeptide (GIP) binding sites in rat brain. Peptides. (1994) 15 (2): 297-302. Kaplan A.M. and Vigna S.R.
  4. Dietary 1-monoolein decreases postprandial GIP release by reducing jejunal transport of glucose and fatty acid in rodents. Am J Physiol Gastrointest Liver Physiol. (2012) 303 (3): G298-310. Shimotoyodome A., et al.

ADDITIONAL INFORMATION

  • Full Name: GIP Active Form ELISA Kit (Rat)
  • Reactivity: Rat
  • Sample Type: EDTA-Plasma
  • Sensitivity: 0.43 pg/ml

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