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GIP Active Form ELISA Kit (Mouse)

  • Created on the 22 February, 2018.

BACKGROUND

Gastric inhibitory polypeptide (GIP) is derived from a 153 amino proprotein that belongs to the secretin family. It has a major role in the stimulation of insulin secretion, however, it is also a weak inhibitor of gastric acid secretion and this helps to protect small intestines from stomach acid damage. Recently, there is evidence to indicate that GIP may be a vital player in bone remodelling, it was discovered that mice which had GIP receptor production disrupted resulted in profound alteration of bone microarchitecture. There are reports to suggest absence of GIP receptors display’s a correlation to resistance to obesity in knockout mice studies.

INTENDED USE

Mouse GIP active ELISA kit is a procedure intended for detecting in vitro quantitative levels of active form mouse gastric inhibitory polypeptide (GIP) using plasma samples. This assay has a minimum sensitivity detection limit of 1.5 pg/ml.

SENSITIVITY

The minimum sensitivity detection limit of gastric inhibitory polypeptide (active form GIP) using this mouse GIP active ELISA kit was approximately 1.5 pg/ml. The dynamic assay range for this kit is 7.8 – 500.0 pg/ml.

REFERENCES

  1. Vaccination against GIP for the treatment of obesity. PLoS One. (2008) 3 (9): e3163. Fulurija A., et al.
  2. Active immunization against (Pro(3))GIP improves metabolic status in high-fat-fed mice. Diabetes Obes Metab. (2010) 12 (9): 744-51. Montgomery I.A., et al.
  3. On the physiology of GIP and GLP-1. Horm Metab Res. (2004) 36 (11-12): 747-54. Review. Holst J.J.
  4. Novel insulin/GIP co-producing cell lines provide unexpected insights into Gut K-cell function in vivo. J Cell Physiol. (2002) 192 (3): 339-50. Ramshur E.B., et al.
  5. GIP as a potential therapeutic agent? Horm Metab Res. (2004) 36 (11-12): 859-66. Review. Meier J.J. and Nauck M.A.

ADDITIONAL INFORMATION

  • Full Name: GIP Active Form ELISA Kit (Mouse)
  • Reactivity: Mouse
  • Sample Type: EDTA-Plasma
  • Sensitivity: 1.5 pg/ml

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