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Gamma-Aminobutyric Acid (GABA) ELISA Kit

  • Created on the 4 March, 2017.

BACKGROUND

Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter, which functions to slow down or weaken neuron signals. This is unlike other neurotransmitters (adrenaline, nor-adrenaline, serotonin, dopamine and glutamate) which all have an excitatory function (i.e. they are responsible for stimulating neuron firing). GABA occurs naturally within the brain where it is vital in regulating the brain activity, there is also evidence to supports its important role in regulating muscle tone. GABA is technically an amino acid, even though it is not part of any protein either in your body or the food you eat. Very small amounts of it can be obtained from food, however, the majority of it is synthesised from glutamate in the body.

Due to its inhibitory function, it plays a vital plays role in anxiety. In this situation, when nerve signals fire too quickly and possess anxiety-inducing signals, GABA is activated and acts in order to slow the signals down and therefore reducing overwhelming feelings of anxiety. However, in individuals with anxiety disorders (e.g. posttraumatic stress, panic disorder and generalised anxiety), gamma-aminobutyric acid does not function as it should and this results in elevated levels of anxiety. There are many remedies and medications which are currently being used for anxiety, benzodiazepines (valium and xanax) are able reduce anxiety through the way they interact with GABA receptors. Whereas, coffee can inhibit GABA and therefore make an individual more buzzed up or anxious.

INTENDED USE

Human GAMA ELISA kit is designed for determining in vitro quantitative concentrations of gamma-aminobutyric acid (GABA) in human plasma, serum and urine samples. This assay has a minimum sensitivity detection limit of 49 ng/ml.

SENSITIVITY

The minimum sensitivity detection limit of gamma-aminobutyric acid (GABA) using this human GABA ELISA kit was approximately 49 ng/ml. The dynamic assay range for this kit is 75 – 7,500 ng/ml.

REFERENCES

  1. Prefrontal cortical gamma-aminobutyric acid transmission and cognitive function: drawing links to schizophrenia from preclinical research. Biol Psychiatry. (2015) 77 (11): 929-39. Review. Tse M.T., et al.
  2. Molecular aspects of age-related cognitive decline: the role of GABA signaling. Trends Mol Med. (2015) 21 (7): 450-60. Review. McQuail J.A., et al.
  3. Brain γ-aminobutyric acid: a neglected role in impulsivity. Eur J Neurosci. (2014) 39 (11): 1921-32. Review. Hayes D.J., et al.
  4. Neurogenesis mediated by gamma-aminobutyric acid and glutamate signaling. J Pharmacol Sci. (2009) 110 (2): 133-49. Review. Nakamichi N., et al.
  5. Hypoxia and GABA shunt activation in the pathogenesis of Alzheimer’s disease. Neurochem Int. (2016) 92: 13-24. Review. Salminen A., et al.

ADDITIONAL INFORMATION

  • Full Name: Gamma-Aminobutyric Acid (GABA) ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum, Plasma, Urine
  • Sensitivity: 49 ng/ml

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