- Created on the 22 February, 2017.
Androstenedione which is also referred to as 17-dione or 4-androsten-3, is a very common precursor for the male and female sex hormones (in particular testosterone and estrone). It is a steroid hormone that is formed as an intermediate step during biochemical pathways that are responsible for producing the androgen (testosterone) and the estrogens (estrone or estradiol). Due to this property many scientist regard it as an important tool evaluating the functional state of these glands.
During pregnancy and at the age of puberty the androstenedione concentrations present in serum is known to increase and these begin to decrease again after menopause. Also, higher levels of androstenedione that are circulating have been found in women with polycystic ovaries or 21-hydroxylase effect. Overproduction tends to be the result of either ovarian dysfunction or maybe it is an adrenal origin. In contrast a significant reduction is identified in patients that have postmenopausal osteoporosis. The production of adrenal androstenedione is regulated by ACTH, while production of gonadal androstenedione is regulated by gonadotropins.
There is a high correlation between serum and saliva androstenedione, this has indicated that any individual difference in androstenedione present is serum can be accurately calculated using this saliva assay, which is a non-invasive alternative sampling procedure.
Human free androstenedione in saliva ELISA kit is an accurate in vitro quantitative method for detecting free androstenedione (4-androsten-3 or 17-dione) in human saliva. This assay has a minimum sensitivity detection limit of 5.0 pg/ml.
The minimum sensitivity detection limit of free androstenedione (17-dione or 4-androsten-3) using this human free androstenedione in saliva ELISA kit was approximately 5.0 pg/ml. The dynamic assay range for this kit is 20.0 – 1,000.0 pg/ml.
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- Measurement of androgens in women. Semin Reprod Med. (2006) 24 (2): 78-85. Review. Stanczyk F.Z.
- Low ratio of androstenedione to testosterone in plasma and saliva of hirsute women. Clin Chem. (1992) 38 (9): 1819-23. Swinkels L.M., et al.
- Full Name: Free Androstenedione Saliva ELISA Kit
- Reactivity: Human
- Sample Type: Saliva
- Sensitivity: 5.0 pg/ml