- Created on the 22 February, 2017.
Human free androstenedione saliva ELISA kit is an accurate in vitro quantitative method for detecting free androstenedione (4-androsten-3 or 17-dione) in human saliva. This assay has a minimum sensitivity detection limit of 5.0 pg/ml.
Androstenedione which is also referred to as 17-dione or 4-androsten-3, is a very common precursor for the male and female sex hormones (in particular testosterone and estrone). It is a steroid hormone that is formed as an intermediate step during biochemical pathways that are responsible for producing the androgen (testosterone) and the estrogens (estrone or estradiol). Due to this property many scientist regard it as an important tool evaluating the functional state of these glands.
During pregnancy and at the age of puberty the androstenedione concentrations present in serum is known to increase and these begin to decrease again after menopause. Also, higher levels of androstenedione that are circulating have been found in women with polycystic ovaries or 21-hydroxylase effect. Overproduction tends to be the result of either ovarian dysfunction or maybe it is an adrenal origin. In contrast a significant reduction is identified in patients that have postmenopausal osteoporosis. The production of adrenal androstenedione is regulated by ACTH, while production of gonadal androstenedione is regulated by gonadotropins.
There is a high correlation between serum and saliva androstenedione, this has indicated that any individual difference in androstenedione present in serum can be accurately calculated using salivary samples, which is a non-invasive alternative sampling procedure.
The minimum sensitivity detection limit of free androstenedione (17-dione or 4-androsten-3) using current human free androstenedione saliva ELISA kit was approximately 5.0 pg/ml. The dynamic range for this assay is 20.0 – 1,000.0 pg/ml.
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- Full Name: Free Androstenedione Saliva ELISA Kit
- Reactivity: Human
- Sample Type: Saliva
- Sensitivity: 5.0 pg/ml