- Created on the 6 February, 2017.
Endothelin-3 (ET-3) is a member of the endothelin family of proteins and in humans is encoded by the EDN3 gene. These are essentially endothelium-derived vasoactive peptides which are involved in a number of different biological functions. The active form of this protein is a 21 amino acid sequence that is formed by the cleavage of the precursor protein. This is a ligand for endothelin receptor type B (EDNRB) and the interaction of this ligand with endothelin is essential for development of many neural crest-derived cell lineages for example enteric neurons and melanocytes. Any mutations in this gene and EDNRB are known to be linked to Waardenburg syndrome (WS) and Hirschsprung disease (HSCR), both of which are neural crest-derived cell congenital disorders.
Endothelin-3 ELISA kit is a reliable quantitative procedure for measuring endothelin-3 (ET-3) in human serum, tissue extracts, cell culture media and EDTA-plasma. This assay has a minimum sensitivity detection limit of 0.36 pg/ml.
The minimum sensitivity detection limit of human endothelin-3 (ET-3) using this endothelin-3 ELISA kit was approximately 0.36 pg/ml. The dynamic assay range for this kit is 0.78 – 100.0 pg/ml.
- Increased plasma levels of big-endothelin-2 and big-endothelin-3 in patients with end-stage renal disease. Life Sci. (2012) 91 (13-14): 729-32. Miyauchi Y., et al.
- Anatomically distinct activation of endothelin-3 and the L-arginine/nitric oxide pathway in the kidney with advanced aging. Biochem Biophys Res Commun. (2005) 327 (1): 234-41. Lattmann T., et al.
- Frequent loss of endothelin-3 (EDN3) expression due to epigenetic inactivation in human breast cancer. Breast Cancer Res. (2009) 11 (3): R34. Wiesmann F., et al.
- Endothelin-3 production by human rhabdomyosarcoma: a possible new marker with a paracrine role. Eur J Cancer. (2006) 42 (5): 680-7. Palladini A., et al.
- Full Name: Endothelin-3 (ET-3) ELISA Kit
- Reactivity: Human
- Sample Type: Serum, Tissue Extracts, EDTA-Plasma, Cell Culture Media
- Sensitivity: 0.36 pg/ml