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ENA-6 Profile ELISA Kit

  • Created on the 2 June, 2017.

BACKGROUND

Extractable nuclear antigen (ENA-6) are intending for profiling one or more autoantibodies that has the ability to react with proteins within the cell nucleus. These are vital in helping to diagnose autoimmune disorder and aiding in distinguishing between different disorders, this is possible because one or more anti-ENA antibodies are found to be associated to specific autoimmune disorders. The ENA profile assay can be either an ENA-4 or an ENA-6 autoantibody tests. The 6-test ENA profile will include anti-Sm, anti-SS-A (Ro), anti-SS-B (La), anti-RNP, Scl-70 and Anti-Jo-1.

INTENDED USE

Human ENA-6 ELISA kit is a procedure for profile screening in-vitro quantitative levels of IgG autoantibodies to extractable nuclear antigens (ENAs) in human serum and plasma samples. This assay has a minimum analytical sensitivity limit of diagn. 86.4%.

Extractable nuclear antigens Sm, RNP/Sm, Jo-1, SS-A (52 and 60 kDa), SS-B and Scl-70 are bound to the microwells.

SENSITIVITY

The minimum detection sensitivity level of human extractable nuclear antigen profile (ENA-6 profile) using this human ENA-6 ELISA kit was diagn. 86.4%. The dynamic assay range for this kit is to a cut-off index 1.0.

REFERENCES

  1. A distinctive autoantibody profile in black female patients with lupus nephritis. Arthritis Rheum. (1993) 36 (11): 1560-5. McCarty G.A., et al.
  2. Relationship between snRNA species contained in nuclear antigens recognized by autoantibodies and the clinical profile in systemic rheumatic diseases. Biomed Pharmacother. (1982) 36 (3): 134-9. Assens C., et al.
  3. Extractable nuclear antigen autoantibodies and their association with other autoantibodies and thymoma in myasthenia gravis. J Neuroimmunol. (1985) 8 (2-3): 185-97. Warlow R., et al.

ADDITIONAL INFORMATION

  • Full Name: ENA-6 Profile ELISA Kit
  • Reactivity: Human
  • Sample Type: Plasma, Serum
  • Sensitivity: 86.4%

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