- Created on the 18 July, 2017.
Human EBV VCA IgM ELISA kit is intended for analysing in-vitro quantitative amounts of human IgM antibodies to Epstein–Barr virus viral-capsid antigen (EBV VCA IgM) using samples of plasma or serum. This EBV VCA-IgM ELISA kit has a minimum analytical sensitivity limit of 0.86 U/ml.
Epstein–Barr virus viral-capsid antigen (EBV-VCA) is a target for the anti-VCA antibodies and is important for the viral capsid of the Epstein–Barr virus (EBV). Anti-VCA antibodies have played a vital role in the diagnosis of infectious mononucleosis. An abnormal result is an indication of either a current or a past EBV infection. The three antibodies which are useful in the test include viral capsid antigen (VCA) IgG, VCA IgM and the Epstein-Barr nuclear antigen (EBNA). The presence of VCA IgG antibodies can indicate that an EBV infection has occurred recently or in the past. Whereas the presence of VCA IgM antibodies along with the absence of EBNA indicate a recent occurrence of the infection. The detection of antibodies to EBNA indicate an infection which occurred in the past (since EBNA develop 6-8 weeks after the time of infection). In cases with primary infections, the sensitivity of anti-VCA IgM and anti-VCA IgG have been estimated to be 100% reliable. EBV VCA-IgM ELISA kit can be used for vaious diagnostic applications.
The minimum detection sensitivity level of IgM directed to Epstein–Barr virus viral-capsid antigen (EBV VCA-IgM) using current human EBV VCA IgM ELISA kit was 0.86 U/ml. The dynamic range for this ELISA assay is 1.0 – 150.0 U/ml.
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- Evaluation of the Architect Epstein-Barr Virus (EBV) viral capsid antigen (VCA) IgG, VCA IgM, and EBV nuclear antigen 1 IgG chemiluminescent immunoassays for detection of EBV antibodies and categorization of EBV infection status using immunofluorescence assays as the reference method. Clin Vaccine Immunol. (2014) 21 (5): 684-8. Corrales I., et al.
- Full Name: EBV VCA IgM ELISA Kit
- Reactivity: Human
- Sample Type: Serum, Plasma
- Sensitivity: 0.86 U/ml