GET A QUOTE

E-Cadherin (CDH1) ELISA Kit

  • Created on the 26 April, 2017.

BACKGROUND

E-Cadherin (short for epithelial cadherin) is also known as cadherin-1 (CDH1) or even uvomorulin is one of the most established member of the cadherin family. It is a tumor suppressor gene which has been designated as cluster of differentiation 324 (CD324) and is made up of 5 cadherin repeats (EC1 to 5) present in the extracellular domain, an intracellular domain which as the ability to bind beta-catenin or p120-catenin and a transmembrane domain.

The loss of E-cadherin expression or function are found to implicate the progression or metastasis of certain cancers. Gene mutations have also been identified to contribute to developing diffusely growing gastric carcinomas. The down regulation of E-cadherin can lead to decreasing the cellular adhesion strength within a tissue which can eventually result in increasing cell motility. This can allow cancer cells to invade the surrounding tissues by crossing the basement membrane. Finally, its expression is considerably reduced or even absent in majority of lobular carcinomas. E-cadherin is regarded as playing a central role in the process of epithelial morphogenesis and can act as a strong invasion suppressor.

INTENDED USE

Human E-cadherin ELISA kit is designed to be used for detecting in vitro quantitative levels of E-cadherin (epithelial cadherin, cadherin-1, CDH1) in human serum, plasma, cell lysates, cell culture supernatant and many other biological fluids. This assay has a minimum sensitivity limit of 0.52 ng/ml.

SENSITIVITY

The minimum detection sensitivity level of epithelial cadherin (CDH1) using this human E-cadherin ELISA kit was 0.52 ng/ml. The dynamic assay range for this kit is 1.0 – 300 ng/ml.

REFERENCES

  1. Gene of the month: E-cadherin (CDH1). J Clin Pathol. (2013) 66 (11): 928-32. Review. Gall T.M. and Frampton A.E.
  2. Cadherins: The Superfamily Critically Involved in Breast Cancer. Curr Pharm Des. (2016) 22 (5): 616-38. Review. Ashaie M.A. and Chowdhury E.H.
  3. E-cadherin and gastric cancer: cause, consequence, and applications. Biomed Res Int. (2014) 2014: 637308. Review. Liu X. and Chu K.M.
  4. Endothelial cadherins in cancer. Cell Tissue Res. (2014) 355 (3): 523-7. Review. Breier G., et al.

ADDITIONAL INFORMATION

  • Full Name: E-Cadherin (CDH1) ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum, Cell Culture Supernatant, Plasma, Cell Lysates, Other Biological Fluids
  • Sensitivity: 0.52 ng/ml

OTHER RELATED ELISA KITS

TESTIMONIALS arrow icon

Your secretory IgA ELISA kit gave good results and I was also really impressed with how quickly we received it.

L. Johnston
PhD Student / University of Glasgow

It is refreshing to know that you have a technical team that is very knowledgeable. I have already recommended your company to other researchers in our department.

Dr. P. Anderson
Lecturer / University College London (UCL)

I am a first time user and found that your instruction manual was very easy to follow. The insulin ELISA kit performed well and I was happy with the results that were generated.

J. Thomas
Senior Technician / Addenbrooke’s Hospital

I carried out a pilot study comparing the performance of many ELISA kits from different suppliers and found your kits to be one of the better performers. We observed good linearity and tight replicates.

Dr. C. Davies
Lead Scientists / AstraZeneca

You are my first point of contact when I am looking to purchase ELISA kits. You have such an easy and simple system, yet it is very effective.

A. Shaw
Purchasing / University of Oxford