- Created on the 26 April, 2017.
E-Cadherin (short for epithelial cadherin) is also known as cadherin-1 (CDH1) or even uvomorulin is one of the most established member of the cadherin family. It is a tumor suppressor gene which has been designated as cluster of differentiation 324 (CD324) and is made up of 5 cadherin repeats (EC1 to 5) present in the extracellular domain, an intracellular domain which as the ability to bind beta-catenin or p120-catenin and a transmembrane domain.
The loss of E-cadherin expression or function are found to implicate the progression or metastasis of certain cancers. Gene mutations have also been identified to contribute to developing diffusely growing gastric carcinomas. The down regulation of E-cadherin can lead to decreasing the cellular adhesion strength within a tissue which can eventually result in increasing cell motility. This can allow cancer cells to invade the surrounding tissues by crossing the basement membrane. Finally, its expression is considerably reduced or even absent in majority of lobular carcinomas. E-cadherin is regarded as playing a central role in the process of epithelial morphogenesis and can act as a strong invasion suppressor.
Human E-cadherin ELISA kit is designed to be used for detecting in vitro quantitative levels of E-cadherin (epithelial cadherin, cadherin-1, CDH1) in human serum, plasma, cell lysates, cell culture supernatant and many other biological fluids. This assay has a minimum sensitivity limit of 0.52 ng/ml.
The minimum detection sensitivity level of epithelial cadherin (CDH1) using this human E-cadherin ELISA kit was 0.52 ng/ml. The dynamic assay range for this kit is 1.0 – 300 ng/ml.
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- Full Name: E-Cadherin (CDH1) ELISA Kit
- Reactivity: Human
- Sample Type: Serum, Cell Culture Supernatant, Plasma, Cell Lysates, Other Biological Fluids
- Sensitivity: 0.52 ng/ml