GET A QUOTE

Dehydroepiandrosterone-Sulfate (DHEA-S) ELISA Kit

  • Created on the 15 February, 2017.

BACKGROUND

Dehydroepiandrosterone-sulfate (DHEA-S) is one of the most abundant adrenal androgen that is in circulation, the majority of the circulating DHEA-S is known to originate either directly from adrenal secretion or as a result of peripheral sulfation of DHEA that has been secreted from the adrenal cortex. It is found to circulate at much higher levels when compared to other androgens or related steroids. DHEA-S does not require to be bound to specific proteins whilst it is in circulation, it also has a long half-life due to it being sulphated and hence is lacking in a circadian rhythm.

In general, the levels of DHEA-S is found to start increasing after the age of seven, reaching a peak at the age of thirty and thereafter it begins to gradually decrease. The determination of DHEA-S is commonly used in many clinical practices and biological research, since it is a more specific product of the adrenals and the importance of plasma assays has been strongly linked with the detection of hirsutism and adrenal hyperplasia. There have been numerous findings showing elevated concentrations of DHEA-S in patients having adrenocortical carcinoma, hirsutism or adrenal hyperplasia. Whereas lower concentrations were detected in patients that suffer from hypopituitarism or adrenal dysfunction.

INTENDED USE

Human DHEA-S ELISA kit is a reliable quantitative procedure for measuring dehydroepiandrosterone-sulfate (DHEA-S) in human serum or plasma samples. This assay has a minimum sensitivity detection limit of 0.002 µg/ml.

SENSITIVITY

The minimum sensitivity detection limit of dehydroepiandrosterone-sulfate (DHEA-S) using this human DHEA-S ELISA kit was approximately 0.002 µg/ml. The dynamic assay range for this kit is 0.03 – 10.0 µg/ml.

REFERENCES

  1. Impact of DHEA(S) and cortisol on immune function in aging: a brief review. Appl Physiol Nutr Metab. (2008) 33 (3): 429-33. Review. Buford T.W. and Willoughby D.S.
  2. Perceived stress at work is associated with lower levels of DHEA-S. PLoS One. (2013) 8 (8): e72460. Lennartsson A.K., et al.
  3. Mechanism of action of anti-aging DHEA-S and the replacement of DHEA-S. Mech Ageing Dev. (2002) 123 (8): 1101-6. Review. Nawata H., et al.
  4. Sex Steroids and Major Psychoses: Which Role for DHEA-S and Progesterone. Neuropsychobiology. (2016) 73 (3): 178-83. Buoli M., et al.

ADDITIONAL INFORMATION

  • Full Name: Dehydroepiandrosterone-Sulfate (DHEA-S) ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum, Plasma
  • Sensitivity: 0.002 µg/ml

OTHER RELATED ELISA KITS

TESTIMONIALS arrow icon

Your secretory IgA ELISA kit gave good results and I was also really impressed with how quickly we received it.

L. Johnston
PhD Student / University of Glasgow

It is refreshing to know that you have a technical team that is very knowledgeable. I have already recommended your company to other researchers in our department.

Dr. P. Anderson
Lecturer / University College London (UCL)

I am a first time user and found that your instruction manual was very easy to follow. The insulin ELISA kit performed well and I was happy with the results that were generated.

J. Thomas
Senior Technician / Addenbrooke’s Hospital

I carried out a pilot study comparing the performance of many ELISA kits from different suppliers and found your kits to be one of the better performers. We observed good linearity and tight replicates.

Dr. C. Davies
Lead Scientists / AstraZeneca

You are my first point of contact when I am looking to purchase ELISA kits. You have such an easy and simple system, yet it is very effective.

A. Shaw
Purchasing / University of Oxford