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Cytomegalovirus (CMV) IgG ELISA Kit

  • Created on the 22 August, 2017.

BACKGROUND

Cytomegalovirus (CMV) is a member of the herpes family of viruses and it can be spread by blood, saliva, urine, breast milk, vaginal fluids and semen. This means that some possible modes of transmission include blood transfusions, organ transplants, breastfeeding and sexual contact. If a person becomes infected then this virus can remain inactive within their body throughout their life. Infants which are born to mothers that are infected with CMV during pregnancy could develop congenital CMV infection. Individuals that have a weak immune system are prone to CMV causing serious diseases/illnesses such as hepatitis, pneumonia, retinitis, encephalitis or colitis). There is the possibility of antiviral treatments which could improve the prognosis in some patients with cytomegalovirus infections. However, currently there are no CMV vaccines that are commercially available. Some of the laboratory techniques that have been used to study this virus are CF and ELISA methods. Serologically either IgG or IgM antibodies can be determined and quantitated, as well as the avidity of the IgG molecules can be measured.

INTENDED USE

Human CMV IgG ELISA kit is intended for analysing in-vitro quantitative levels of human IgG antibodies to cytomegalovirus (CMV) in plasma or serum samples. This assay has a minimum analytical sensitivity limit of 1.29 U/ml.

SENSITIVITY

The minimum detection sensitivity level of human cytomegalovirus IgG using this human CMV IgG ELISA kit was 1.29 U/ml. The dynamic assay range for this kit is 1.0 – 90.0 U/ml.

REFERENCES

  1. Performance of a cytomegalovirus IgG enzyme immunoassay kit modified to measure avidity. Clin Vaccine Immunol. (2014) 21 (6): 808-12. Prince H.E., et al.
  2. Improvement of cytomegalovirus avidity testing by adjusting the concentration of CMV-specific IgG in test samples. J Clin Virol. (2006) 35 (3): 303-9. Dangel V., et al.
  3. Detection of human cytomegalovirus IgG antibody using automated immunoassay with recombinant antigens gives uniform results to established assays using whole virus antigens. Pathology. (2010) 42 (6): 578-80. Baalawi F., et al.
  4. Evaluation of a novel array-based toxoplasma, rubella, cytomegalovirus, and herpes simplex virus IgG enzyme linked immunosorbent assay and its comparison with virion/serion enzyme linked immunosorbent assays. Ann Lab Med. (2014) 34 (1): 38-42. Wu D., et al.
  5. IgG subclass antibodies to human cytomegalovirus (CMV) in normal human plasma samples and immune globulins and their neutralizing activities. Biologicals. (1996) 24 (2): 117-24. Gupta C.K., et al.

ADDITIONAL INFORMATION

  • Full Name: Cytomegalovirus (CMV) IgG ELISA Kit
  • Reactivity: Human
  • Sample Type: Plasma, Serum
  • Sensitivity: 1.29 U/ml

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