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CXCL9 (MIG) ELISA Kit

  • Created on the 17 March, 2017.

BACKGROUND

Chemokine (C-X-C motif) ligand 9 (CXCL9) which can also be called monokine induced by gamma interferon (MIG), belongs to a family of cytokines which are known as CXC chemokines. MIG family is closely related with CXCL10 and CXCL11 chemokines, both of these are located very close to the gene for human CXCL9 on chromosome 4. It is induced by IFNγ and is mainly secreted by macrophages, the main roles of CXCL9 are in inflammation by its binding to a receptor that can be selectively expressed in activated T-lymphocytes and to recruit leukocytes to sites intended for infections. These properties makes it a critical mediator of T-lymphocyte migration during T-cell dependent immune responses.

Similar to IP-10, MIG has the ability to bind to the chemokine receptor CXCR3 in TH1 immune reactions and can also exhibit inhibitory functions in neovascularisation. Furthermore, MIG is an inhibitor for hematopoietic progenitor cells whilst also displaying anti-tumor effects. This has led to the belief that it may play vital functions in the mediation of cell recruitment and activation which is necessary for repairing damaged tissue and inflammation.

INTENDED USE

CXCL9 ELISA kit is intended for detecting in vitro quantitative amounts of CXCL9 (MIG) in human biological samples. This assay has a minimum detection limit of < 3.13 ng/ml.

SENSITIVITY

The minimum detection sensitivity level of CXCL9 (MIG) using this human CXCL9 ELISA kit was approximately 3.13 ng/ml. The dynamic assay range for this kit is 0.625 – 10 ng/ml.

REFERENCES

  1. Mig and IP-10: CXC chemokines that target lymphocytes. J Leukoc Biol. (1997) 61 (3): 246-57. Review. Farber J.M.
  2. The CXC chemokines IP-10 and Mig are essential in host defense following infection with a neurotropic coronavirus. Adv Exp Med Biol. (2001) 494: 323-7. Review. Liu M.T., et al.
  3. Role of autophagy in monokine induced by interferon γ (Mig) production during adenovirus-hepatitis B virus infection. Hepatogastroenterology. (2012) 59 (116): 1245-50. Xia Y., et al.
  4. Human eosinophils produce the T cell-attracting chemokines MIG and IP-10 upon stimulation with IFN-gamma. J Leukoc Biol. (2004) 76 (3): 685-91. Dajotoy T., et al.

ADDITIONAL INFORMATION

  • Full Name: CXCL9 (MIG) ELISA Kit
  • Reactivity: Human
  • Sample Type: Biological Samples
  • Sensitivity: < 3.13 ng/ml

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