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Chikungunya Virus IgG Capture ELISA Kit

  • Created on the 13 July, 2017.

BACKGROUND

Chikungunya is a mosquito-borne viral disease that belongs to the alphavirus genus Togaviridae family. The virus can be transmitted from one human to another by the bites from an infected female mosquitoes. Some of the common symptoms are severe joint pain, muscle pain, fever, fatigue, rash and headache. Chikungunya disease is found to shares some clinical signs with are very similar to zika and dengue. At present it has been identified in over 60 countries that include Europe, America, Africa and Asia. There are several methods which have been used for its diagnosis, for example serological test like ELISA have been routinely used to confirm the presence of either IgG or IgM anti-chikungunya antibodies. Also, it have been identified that the levels of IgM antibody are at their highest between 3 to 5 weeks following the onset of illness and this can persist for up to 2 months.

INTENDED USE

Human Chikungunya virus-IgG ELISA kit is a method for detecting in-vitro quantitative amounts of IgG class antibodies against Chikungunya virus in human plasma or serum. This assay has a minimum analytical sensitivity limit to a diagn. >90%.

SENSITIVITY

The minimum detection sensitivity level of human Chikungunya virus IgG using this human Chikungunya virus-IgG ELISA kit was to a a diagn. >90%. The dynamic assay range for this kit is to a specific cut-off point.

REFERENCES

  1. Analysis of antibody response (IgM, IgG, IgG3) to Chikungunya virus using panel of peptides derived from envelope protein for serodiagnosis. Clin Chem Lab Med. (2014) 52 (2): 297-307. Verma P., et al.
  2. Early neutralizing IgG response to Chikungunya virus in infected patients targets a dominant linear epitope on the E2 glycoprotein. EMBO Mol Med. (2012) 4 (4): 330-43. Kam Y.W., et al.
  3. Enhanced production of Chikungunya virus-like particles using a high-pH adapted spodoptera frugiperda insect cell line. PLoS One. (2014) 9 (4): e94401. Wagner J.M., et al.
  4. Risk factors for symptomatic and asymptomatic chikungunya infection. Trans R Soc Trop Med Hyg. (2013) 107 (12): 789-96. Nakkhara P., et al.
  5. Inflammatory cytokine expression is associated with chikungunya virus resolution and symptom severity. PLoS Negl Trop Dis. (2011) 5 (8): e1279. Kelvin A.A., et al.

ADDITIONAL INFORMATION

  • Full Name: Chikungunya Virus IgG Capture ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum, Plasma
  • Sensitivity: diagn. >90%

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