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CCL17 (TARC) ELISA Kit

  • Created on the 17 March, 2017.

BACKGROUND

Chemokine (C-C motif) ligand 17 (CCL17) which is also commonly known as thymus and activation regulated chemokine (TARC), is a cytokine which is part of the CC chemokine family. The gene can be found located on chromosome 16, along with two other chemokines known as CX3CL and CCL22. The chemokine has the ability to bind and induce specific chemotaxis activity within T cells and it carries this function out by interacting with the CCR4 receptor.

CCL17 is found to be produced in lymph node dendritic cells, thymic dendritic cells, CD4+ T cells, monocytes, Reed-Sternberg cells, bronchial epithelial cells, fibroblasts and keratinocytes. It is expressed constitutively in thymus, but only transiently in peripheral blood mononuclear cells that have been phyto-hemagglutinin stimulated. One of the main function of CCL17 is the promotion of Th2 cell recruitment to sites of inflammation and in inducing platelet degranulation and aggregation. The standard used in this ELISA assay is recombinant human CCL17 which is made up of 71 amino acids and has a molecular weight of 8Kda.

INTENDED USE

CCL17 ELISA kit is procedure for measuring in vitro quantitative concentrations of CCL17 (TARC) in human serum, cell culture supernatant and plasma (EDTA, heparin). This assay has a minimum detection limit of < 1.0 pg/ml.

SENSITIVITY

The minimum detection sensitivity level of CCL17 (TARC) using this human CCL17 ELISA kit was approximately 1.0 pg/ml. The dynamic assay range for this kit is 31.2 – 2,000 pg/ml.

REFERENCES

  1. Chemokine (C-X-C motif) ligand (CXCL)10 in autoimmune diseases. Autoimmun Rev. (2014) 13 (3): 272-80. Review. Antonelli A., et al.
  2. CCR4 as a novel molecular target for immunotherapy of cancer. Cancer Sci. (2006) 97 (11): 1139-46. Review. Ishida T. and Ueda R.
  3. The biological environment of Hodgkin’s lymphoma and the role of the chemokine CCL17/TARC. Prague Med Rep. (2009) 110 (1): 35-41. Review. Hnátková M., et al.
  4. Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseases. J Dermatol Sci. (2006) 43 (2): 75-84. Review. Saeki H. and Tamaki K.
  5. Cytokines and chemoattractants in allergic inflammation. Mol Immunol. (2002) 38 (12-13): 881-5. Review. Romagnani S.

ADDITIONAL INFORMATION

  • Full Name: CCL17 (TARC) ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum , Plasma (EDTA, Heparin), Cell Culture Supernatant
  • Sensitivity: < 1.0 pg/ml

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